Quality assessment of the different brands of diclofenac tablets marketed in Ilorin Metropolis: A pharmaceutical and public health perspective
| dc.contributor.author | Abdullahi, ST; Olanipekun, OC; Njinga, NS; Eniayewu, OI; Bamidele, OD; Bakare-Odunola, MT; Shittu, AO; Soyinka, JO | |
| dc.date.accessioned | 2021-10-26T10:18:47Z | |
| dc.date.available | 2021-10-26T10:18:47Z | |
| dc.date.issued | 2020-11-01 | |
| dc.description.abstract | Background: The quality of a medicinal product is an important factor for its safety and efficacy. Poor-quality medicines are a major impediment to improvements in public health. This study assessed the pharmaceutical quality of different brands of diclofenac (DCF) tablets in Ilorin metropolis. Methods: Four randomly selected brands of diclofenac potassium tablets (coded: DCF-A, DCF-B, DCF-C and DCF-D) were obtained from pharmaceutical outlets, and quality parameters were evaluated according to Pharmacopeial methods. The potency of tablets was determined spectrophotometrically based on the measurement of maximum absorbance at a wavelength of 276 nm in doubly distilled water. Results: Method validation according to the International Council for Harmonization guidelines showed acceptable sensitivity (limit of detection of 0.3886 μg/mL and limit of quantification of 1.1775 μg/mL), precision (% relative standard deviation range of 0.72 – 1.54), accuracy (% recovery range of 98.9 – 101.3). Average contents of active diclofenac were 45, 98, 103 and 105% for DCF-A, DCF-B, DCF-C and DCF-D respectively. DCF-A brand was not only substandard but falsified based on British Pharmacopoeia potency specification range of 95 – 105%. Conclusion: A substandard and falsified brand of diclofenac tablets was detected. Drug regulatory authority must ensure periodic post-registration surveillance of licensed pharmaceutical products marketed in the country to secure the health and safety of the populace. | en_US |
| dc.identifier.citation | 2. Abdullahi, S. T., Olanipekun, O. C., Njinga, N. S., Eniayewu, O. I., Bamidele, O. D., Bakare-Odunola, M. T., Shittu, A. O. & Soyinka, J. O. (2020): Quality assessment of the different brands of diclofenac tablets marketed in Ilorin Metropolis: A pharmaceutical and public health perspective. Nigerian Journal of Pharmacy 54(2): 49-65. | en_US |
| dc.identifier.issn | 0331 – 670X | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/20.500.12484/6737 | |
| dc.language.iso | en | en_US |
| dc.publisher | Nigerian Journal of Pharmacy | en_US |
| dc.subject | diclofenac tablets | en_US |
| dc.subject | spectrophotometric analysis | en_US |
| dc.subject | quality | en_US |
| dc.subject | substandard | en_US |
| dc.subject | falsified medicines | en_US |
| dc.title | Quality assessment of the different brands of diclofenac tablets marketed in Ilorin Metropolis: A pharmaceutical and public health perspective | en_US |
| dc.type | Article | en_US |
| dc.type | Preprint | en_US |