Aqueous Leaf Extract of Cola Acuminata (Malvaceae) Modulates Cholinergic Neurotransmission in Scopolamine-induced Memory Impairment in Male Wistar Rats.
| dc.contributor.author | Ayinla M.T | |
| dc.contributor.author | Asuku, A.O. | |
| dc.contributor.author | Bangwai, T. B. | |
| dc.contributor.author | Owoyele, B.V. | |
| dc.date.accessioned | 2025-05-03T16:20:33Z | |
| dc.date.available | 2025-05-03T16:20:33Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | This study investigated the effects of aqueous leaf extract of Cola acuminata (ALECA) on cholinergic neurotransmission in scopolamine-induced rat model of memory impairment. A total of thirty-five male Wistar rats (178 12.32 g) were allotted into 7 groups (I–VII) at random as follows: I: control, received 5ml/kg body weight (body wt) of distilled water, II: received scopolamine alone (3mg/kg body wt), III: received Donepezil (2mg/kg body wt) plus scopolamine (3mg/kg body wt), IV: received Cola acuminata (50mg/kg body wt) plus scopolamine (3mg/kg body wt), V: received Cola acuminata, (100mg/kg body wt) plus scopolamine (3mg/kg body wt), VI: received Cola acuminata (300mg/kg body wt) plus scopolamine (3mg/kg body wt), VII: received Cola acuminata (400mg/kg body wt) plus scopolamine (3mg/kg body wt) for seven days. ALECA and distilled water were orally administered daily while scopolamine was injected intraperitoneally daily for seven days. Behavioural test were conducted using Morris water maze, light and dark box to assess learning and memory. Acetylcholinesterase (AchE) activity in the brain was assayed using Ellman’s method. Scopolamine caused a significant impairment in memory through decreased probing frequency and increase in escape latency time (memory index) in Light and Dark Box and Morris Water Maze respectively. Treatment with different doses of ALECA prevented cognitive impairment induced by scopolamine through increased probing frequency and decrease in escape latency time. However, this effect is not dose dependent and it compares favourably with the donepezil group (reference drug) The mechanism of action of ALECA was also investigated through estimation of brain Acetylcholine esterase. We found that the brain’s acetylcholinesterase activity significantly increased in response to scopolamine. While a significant (p<0.05) decline in acetylcholinesterase activity was seen after treatment with ALECA., and this effect compares favourably with donepezil group. The effect of ALECA is also not dose dependent. This study concludes that ALECA treatment could improve memory function in scopolamine-induced model of dementia through the inhibition of acetylcholine esterase activity. | |
| dc.identifier.citation | Ayinla, M.T. Asuku, A.O., Bangwai, T. B, & Owoyele, B.V. (2022): Aqueous Leaf Extract of Cola Acuminata (Malvaceae) Modulates Cholinergic Neurotransmission in Scopolamine-induced Memory Impairment in Male Wistar Rats. Biokemistri. 34(3); 34248-34259, an International Journal Published by the Society for Experimental Biology of Nigeria, | |
| dc.identifier.issn | 0795-8080 | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/123456789/16035 | |
| dc.language.iso | en | |
| dc.publisher | The Society for Experimental Biology of Nigeria, | |
| dc.relation.ispartofseries | vol 34 no. 3; 34248-34259 | |
| dc.subject | Cola acuminata | |
| dc.subject | (Malvaceae) Acetylcholinesterase | |
| dc.subject | Scopolamine | |
| dc.subject | Morris water maze | |
| dc.subject | Memory | |
| dc.subject | Donepezil | |
| dc.title | Aqueous Leaf Extract of Cola Acuminata (Malvaceae) Modulates Cholinergic Neurotransmission in Scopolamine-induced Memory Impairment in Male Wistar Rats. | |
| dc.type | Article |