ANTI-INFLAMMATORY AND ANALGESIC POTENTIALS OF THE ROOT BARK EXTRACT OF SABA COMORENSIS (BOJER) PICHON (APOCYNACEAE) USED IN NIGERIAN TRADITIONAL MEDICINE
| dc.contributor.author | Attah, F. A | |
| dc.contributor.author | Chukwudulue, U. M. | |
| dc.contributor.author | Diyaolu, O. A. | |
| dc.contributor.author | Njinga, N. S. | |
| dc.contributor.author | Abdullahi, A. A. | |
| dc.contributor.author | Agunu, A. | |
| dc.contributor.author | Musa, K. Y. | |
| dc.date.accessioned | 2021-12-10T12:14:46Z | |
| dc.date.available | 2021-12-10T12:14:46Z | |
| dc.date.issued | 2020-03 | |
| dc.description.abstract | Painful and inflammatory diseases such as arthritis, backache, headaches, asthma and peptic ulcer disease are widespread and highly prevalent. The existing drugs for these conditions are liable to sub-optimal efficacy, intolerable adverse effects, prohibitive costs or limited availability. This scenario calls for renewed search for additional anti-inflammatory and analgesic agents. Hence, in line with the Traditional uses of plants, this study investigated the ethanol extract of Saba comorensis (Bojer ex. A.DC.) Pichon, for its safety, anti-inflammatory and analgesic effects in rodents using standard experimental protocols. The LD50 (i.p.) for the ethanol extract obtained from the geometric mean of doses was 770 mg/kg. Compared with the negative controls, the ethanol extract exhibited significant (p<0.05) and dose-dependent anti-inflammatory, ulcerogenic and dose-independent analgesic effects, while the petroleum extract did not induce any significant ulcerogenic effects. These findings suggest Saba comorensis ethanol root extract may be relatively safe and possesses anti-inflammatory and analgesic properties and may justify its use as traditional remedy for painful and inflammatory conditions. There is the need to investigate the study plant further for anti-inflammatory and analgesic drug discovery | en_US |
| dc.identifier.issn | ISSN: 0189-823X | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/20.500.12484/7138 | |
| dc.language.iso | en | en_US |
| dc.publisher | Nigerian Journal of Pharmaceutical Sciences | en_US |
| dc.relation.ispartofseries | Vol. 19;No1 | |
| dc.subject | Ethnomedicine | en_US |
| dc.subject | inflammation | en_US |
| dc.subject | gastric ulcers | en_US |
| dc.subject | nociception | en_US |
| dc.subject | Rodents | en_US |
| dc.title | ANTI-INFLAMMATORY AND ANALGESIC POTENTIALS OF THE ROOT BARK EXTRACT OF SABA COMORENSIS (BOJER) PICHON (APOCYNACEAE) USED IN NIGERIAN TRADITIONAL MEDICINE | en_US |
| dc.type | Article | en_US |