Hypoglycaemic and Antioxidative Properties of Freeze-Dried Garcinia Kola Seeds in Type 2 Diabetics and Non-Diabetics with Chronic Foot/Leg Ulcer in Ibadan, Nigeria: A case-control clinical study

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dc.contributor.authorElizabeth, Bosede Bolajoko
dc.contributor.authorAugustine, Anayochukwu Onyeaghala
dc.contributor.authorOlubayo, Michael Akinosun
dc.contributor.authorAlfred, Francis Attah
dc.contributor.authorOlufemi, Joseph Adewumi
dc.contributor.authorAdefunke, Temiloa Adeoti
dc.contributor.authorAyodele, Olukayode Iyun
dc.contributor.authorAdesoji, Adedipe Fasanmade
dc.contributor.authorJones, Olanrewaju Moody
dc.contributor.authorAye, Aye Khine
dc.date.accessioned2021-12-10T09:42:01Z
dc.date.available2021-12-10T09:42:01Z
dc.date.issued2021-05
dc.description.abstractINTRODUCTION The antidiabetic and antioxidative properties of Garcinia kola (GK) seed extracts have been well documented in animal studies; however, data on freeze-dried powder of GK seeds (FDGK) in humans are scarce. This study investigated the effect of 8-weeks supplementation of FDGK on glycaemic control and oxidative stress levels in Type 2 diabetics with or without foot/leg ulcer and compared with nondiabetics with or without chronic foot/leg ulcer in Ibadan, Nigeria. MATERIALS AND METHODS Thirty diabetics with foot/leg ulcer (DFU), 30 diabetics without ulcer (T2DM), 30 non-diabetics with chronic foot/leg ulcer (NDCU) and 30 non-diabetics without ulcer (NDC) were divided into: subgroup-1 (250mgGK); subgroup-2 (500mgGK); subgroup-3 (No-supplementation). Plasma glucose (FPG), glycated haemoglobin-A1c (HbA1c), total plasma peroxides (TPP), total antioxidant status (TAS), oxidative stress index (OSI), antioxidant-micronutrients were determined in fasting blood samples. Wounds were clinically assessed and rated using modified ABDEFS. RESULTS All participants supplemented with 250mgGK or 500mgGK for 8 weeks showed decreases in TPP and OSI with improvement in wound healing, increases in TAS and antioxidant-micronutrients (p<0.05). In addition, significant decreases in FPG were observed in DFU and T2DM supplemented with 250mgGK, and also in NDC supplemented with 500mgGK. In non-supplemented subgroups, increases in TPP and OSI with decreases in TAS and antioxidant-micronutrients (p<0.05) were observed. CONCLUSION Supplementation with Garcinia kola could be used as an adjunct for prevention and treatment of diabetes mellitus complicated with or without foot/leg ulcer RECOMMENDATIONS Caution must be taken when used as prophylactic in non-diabetics to prevent occurrence of hypoglycaemia.en_US
dc.description.sponsorshipThomas Bassir Biomedical Foundation (TBBF) Seed Grant Programen_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/7127
dc.language.isoenen_US
dc.publisherAfrican Journal of Health Sciencesen_US
dc.relation.ispartofseriesVol. 34;Num. 3
dc.subjectFreeze-Dried Garcinia Kola Seedsen_US
dc.subjectHypoglycaemic Agenten_US
dc.subjectAntioxidant Agenten_US
dc.subjectChronic Ulceren_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.titleHypoglycaemic and Antioxidative Properties of Freeze-Dried Garcinia Kola Seeds in Type 2 Diabetics and Non-Diabetics with Chronic Foot/Leg Ulcer in Ibadan, Nigeria: A case-control clinical studyen_US
dc.typeArticleen_US

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