Responses of Selected Inflammatory, Kidney and Liver Function Markers in Serum of Nigerian Children with Severe Falciparum Malaria to Treatment with Artesunate/ArtemetherLumefantrine Combination Therapy

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dc.contributor.authorOkoli, C.A.
dc.contributor.authorIgunnu, Adedoyin
dc.contributor.authorMalomo, S.O.
dc.contributor.authorAdebayo, J.O.
dc.contributor.authorOguche, S.
dc.date.accessioned2020-05-29T15:04:04Z
dc.date.available2020-05-29T15:04:04Z
dc.date.issued2019
dc.description.abstractMalaria tolerance is a defence strategy that limits the damage caused by Plasmodium species irrespective of pathogen burden. The mechanisms responsible for this, responses of these mechanisms and their impact on organs to treatment have not been extensively studied. Thus, in this study, serum levels of selected pro- and anti-inflammatory markers, liver and kidney function indices with leucocytes indices in 100 children (1-10 years) with severe falciparum malaria were determined before treatment, at 48 hours during treatment and 48 hours after treatment with WHO recommended dosage of artesunate/artemether-lumefantrine combination therapy using standard methods. Data were analysed using SPSS, differences were considered significant at p<0.05. The results revealed that the serum levels of interleukin-12 (IL-12), interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), C-reactive protein (CRP), nitric oxide (NO), creatinine, albumin, total protein and conjugated bilirubin were not significantly changed at higher parasite densities before treatment. Only serum IL-4, CRP, total bilirubin, urea and creatinine levels and alanine aminotransferase activity were significantly reduced below the ranges of those with severe malaria. The results suggest a self-protective feed-back control, indicating tolerance, which reduced the adverse effects of the disease on kidney and liver functions at higher parasite densities. The results also suggest serum IL-12, IL-4, TNF-α, IFN-γ, CRP and NO levels as immune-protective markers for tolerance and serum IL-4 level as an effective marker for disease severity and recovery from the disease in children with severe malaria.en_US
dc.description.sponsorshipFunded by the authors.en_US
dc.identifier.urihttps://www.ajol.info/index.php/ajbr/article/view/190608
dc.identifier.urihttp://hdl.handle.net/123456789/4100
dc.language.isoenen_US
dc.publisherDepartment of Physiology, College of Medicine, University of Ibadan, Nigeriaen_US
dc.relation.ispartofseriesAfrican Journal of Biomedical Research;Vol. 22; 165-177
dc.subjectImmunityen_US
dc.subjectfalciparum malariaen_US
dc.subjectinflammatory markersen_US
dc.subjectchildrenen_US
dc.titleResponses of Selected Inflammatory, Kidney and Liver Function Markers in Serum of Nigerian Children with Severe Falciparum Malaria to Treatment with Artesunate/ArtemetherLumefantrine Combination Therapyen_US
dc.typeArticleen_US

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