Effects of MOF6 Fraction from Ethanolic Extract of the Leaves of Moringa oleifera against Sodium Arsenite-Induced Hepatotoxicity in Rats

Simple item page
dc.contributor.authorAmeen, Mubarak
dc.contributor.authorAdelaja, Akinlolu
dc.contributor.authorMukadam, Abdulhamid
dc.contributor.authorMuheen, Biliaminu
dc.contributor.authorAjiboye, Olaolu
dc.contributor.authorYahya, Rahmat
dc.contributor.authorAbdulrahman, Bashir
dc.contributor.authorOyetunji, Oyepeju
dc.contributor.authorRotimi, Mojishola
dc.contributor.authorNejo, Victoria
dc.contributor.authorOmotoso, Gabriel
dc.date.accessioned2022-11-11T08:06:19Z
dc.date.available2022-11-11T08:06:19Z
dc.date.issued2020
dc.description.abstractMoringa oleifera (MO) is a plant of significant medicinal importance. The dried leaves of MO were pulverized, extracted with ethanol and fractionated using column chromatography to provide seven fractions (MOF1-7) with MOF6 having the best preliminary antioxidant potential. Therefore, this study evaluated the hepatoprotective potentials of MOF6 in sodium arsenite (SA)-induced hepatotoxicity in rats. Thirty-five adult male Wistar rats were randomly divided into seven groups of five rats each. Control Group I received normal saline. Groups II and III received 20 mg/kg body weight (bw) of SA for 3 and 6 weeks, respectively. Groups IV and V received 20 mg/kg bw of SA for 3 weeks followed by treatment with 5.0 and 7.5 mg/kg bw of fraction MOF6, respectively, for 6 weeks. Groups VI and VII received only 5.0 and 7.5 mg/kg bw of fraction MOF6, respectively, for 6 weeks. Antioxidant (lipid peroxidation) and biochemical analyses of liver enzymes of all rats were carried out after the completion of experimental procedures. Results showed statistically significant lower mean values (p ≤ 0.05) of malondialdehyde (MDA), acid phosphatase (ACP) and γ-glutamyl transferase (GGT) in rats of Groups IV and V compared with Group III. However, there were statistically significant higher mean values (p ≤ 0.05) of alkaline phosphatase (ALP) in Groups IV and V compared with Groups I and III. In conclusion, these results implied that fraction MOF6 has antioxidant and hepatoprotective potentials. However, results of ALP analyses implied that MOF6 possibly augmented SA-induced hepatotoxicity in rats.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/7895
dc.language.isoenen_US
dc.publisherEthiopian Pharmaceutical Associationen_US
dc.subjectMoringa oleiferaen_US
dc.subjectcolumn fractionsen_US
dc.subjectsodium arseniteen_US
dc.subjecthepatotoxicityen_US
dc.subjectlipid peroxidationen_US
dc.titleEffects of MOF6 Fraction from Ethanolic Extract of the Leaves of Moringa oleifera against Sodium Arsenite-Induced Hepatotoxicity in Ratsen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2020_Ethiop. Pharm. J. 36-i-viii_ Ameen et al_Effects of MOF6 Fraction from Ethanolic Extract of the Leaves of Moringa oleifera - Copy.pdf
Size:
1.05 MB
Format:
Adobe Portable Document Format
Description:
Main Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections