Effect of testosterone supplementation on renal function in male albino rats.
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Date
2018
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Faculty of Basic Medical Sciences, Lagos State University College of Medicine
Abstract
Objectives: Testosterone is an anabolic steroid and it is secreted primarily by the testicles in males.
Androgens have been shown to increase tubular sodium and water reabsorption and activate various
vasoconstrictor systems in the kidneys. Testosterone increases blood pressure and may also influence renal
electrolyte excretion.
Methods: Fifteen adult male rats weighing 100 – 150g were randomly divided into three groups of five (5)
rats each. Group 1 rats (Control) were given normal saline intramuscularly (IM). Group 2 rats were given
3mg/kg body weight (bw) of testosterone IM while Group 3 rats were given 9mg/kg bw testosterone IM for
two weeks. All rats were allowed normal chow and water ad libitum. The animals were sacrificed under
anaesthesia and blood samples collected through cardiac puncture.
Results: Plasma urea levels of both low (2.02±0.23mmol/L) and high (10.3±0.61mmol/L) dose
testosterone-treated animals were higher when compared with the Control group (1.94±0.07mmol/L), but
the difference was only significant (p<0.05) in the high dose group. Asignificant (p<0.05) increase in plasma
creatinine level in animals injected with low dose testosterone (33.0±2.46µmol/L) and high dose
testosterone (46.0±5.67µmol/L) was observed when compared to the control group (25.2±3.91µmol/L).
Conclusion: It was concluded from this study that exogenous administration of testosterone may alter
normal kidney functions shown by elevated levels of urea and creatinine, but these could also be dose depend
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Keywords
Citation
Testosterone Supplementation, Renal function, Electrolyte, Urea, Creatinine.