Alterations of Kiss 1 receptor, GnRH receptor and nuclear receptors of the hypothalamopituitary-ovarian axis following low dose bisphenol-A exposure in Wistar rats
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Date
2021
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Korean Association of Anatomists
Abstract
Bisphenol A is a chemical used primarily as a monomer in the production of polycarbonate plastics and epoxy
resins. It is a synthetic chemical compound that is produced in billions of pounds annually, and tagged as an endocrine
disruptor. Bisphenol A is a high production synthetic chemical compound that is used in the production of many
consumables and equipments of daily consumption and use by man. Growing interest in possible health threats posed
by endocrine disrupting chemicals (bisphenol-A inclusive), as these substances are in our environment, food, and many
consumer products. Therefore, this study aims to determine bisphenol-A effects on the hypothalamo-pituitary-ovarian axis,
and role of melatonin in this regard. Forty-two Wistar rats were bred, grouped into 7, with each group consisting of 6 rats.
Experimental groups were administered low and high doses of bisphenol-A and melatonin, starting from day 19, and was
continued for 7 weeks orally. They were left to develop into full adults and were sacrificed on day 120±4 days. Blood samples,
hypothalamus, pituitary and ovarian tissues were excised for biochemical and tissue antioxidants assays as well as genetic
studies. Results show elevated gonadotropin and androgen levels. There was disruption of reactive oxygen species in the
ovarian tissues, as well as alterations in the expression of genes that regulate reproduction at the hypothalamus and pituitary
levels. Conclusion of early exposure to bisphenol-A is associated with prolonged duration of disruption of reproductive
functions in female Wistar rats, which persist long after cessation of the exposure. Melatonin antioxidant effects give some
promising outturns against bisphenol-A induced toxicities.
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Keywords
Bisphenol A, Endocrine disruptors, Reproduction, Hypothalamo-pituitary-ovarian axis, Melatonin
Citation
Kadir R.E., Imam A., Olajide O.J. & Ajao M.S. (2021). Alterations of Kiss 1 receptor, GnRH receptor and nuclear receptors of the hypothalamopituitary-ovarian axis following low dose bisphenol-A exposure in Wistar rats. Anatomy and Cell Biology. 54(2):212-224. Published by Korean Association of Anatomists. Available online at https://acbjournal.org/journal/list.html?pn=vol&TG=vol&sm=&s_v=54&s_n=2&year=