Acetate causes renoprotection like androgen and mineralocorticoid receptors blockade in testosterone-exposed pregnant rats
No Thumbnail Available
Date
2021-01-21
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
The kidney plays a critical role in human health and deviation from its normal function can lead to severe morbidity and
mortality. Exposure to excess testosterone in women has been linked to several disorders, including kidney disorder and act ing undoubtedly through androgen receptor (AR), whereas the involvement of mineralocorticoid receptor (MR) is unclear.
Likewise, the renal efect of sodium acetate (SAc) during late gestational exposure to testosterone is not well known. We
hypothesized that SAc or MR blockade would protect the kidney of testosterone-exposed pregnant rats against glutathione
and adenosine depletion. Twenty-fve pregnant Wistar rats were treated (sc) with olive oil, testosterone propionate (0.5 mg/
kg) singly or in combination with SAc (200 mg/kg; p.o.), androgen receptor (AR) blocker, futamide (Flu; 7.5 mg/kg; p.o.)
or (MR) blocker, eplerenone (Eple; 0.5 mg/kg) between gestational days 14 and 19. Glutathione, adenosine and nitric oxide
were decreased while uric acid (UA), xanthine oxidase (XO), malondialdehyde (MDA), lactate dehydrogenase activity and
free fatty acids were increased in the kidneys of gestational rats exposed to testosterone. Also, plasma urea and creatinine
were elevated. SAc and Eple reversed tested testosterone-induced efects in gestational rats. The exposure to testosterone
impairs renal antioxidant defense via AR and MR during late gestation in pregnant rats. The study also provides evidence
that sodium acetate protects the kidneys of gestational testosterone-exposed rats against defective antioxidant defense in
like manner as MR or AR antagonist.
Description
Keywords
Maternal testosterone · Mineralocorticoid receptor · Androgen receptor · Renal anti-oxidant · SCFA, Mineralocorticoid receptor, Androgen receptor, Renal antioxidant, SCFA
Citation
12.Usman, T.O., Adeyanju, O.A., Areola, E.D., Badmus, O.O., Oyeyipo, I.P., Olaniyi, K.S., Oyabambi, A.O., Olatunji, L.A. (2021). Acetate causes renoprotection like androgen and mineralocorticoid receptors blockade in testosterone-exposed pregnant rats. Molecular Cell Biochemistry, 476 (4), 1861-1870, Published by Springer. Available online at: Volume 476, Issue 4 | Molecular and Cellular Biochemistry