Rejuvenative and prophylactic effects of Moringa on lead-induced heart tissue damage in adult male Wistar Rats Models.
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
International Moringa and Nutraceutical Research Society
Abstract
Moringa is a plant that is rich in antioxidants and other substances with vital health benefits. Previous reports have indicated that healing effects of moringa in instances of trauma to body tissues. This experiment was aimed at investigating the potency of the prophylactic as well as the rejuvenative effects of Moringa phytochemical extracts on lead-induced tissue damage to the hearts of adult male Wistar rats. A total fo52 (n=25) adult male Wistar rats were used for the investigation; these were divided into five groups labelled AE-, each group comprising five animals (n=25). Animals in Group A served as control while those in Groups B - E animals served as tests. Animals in Group B were administered moringa leaf extract only; Group C animals were administered lead only; group D animals received lead and moringa concurrently while group E animals received lead for the first half of the treatment period and subsequently moringa extracts for the other half. All administrations lasted 16 days; using dosages of 50mg/kg body weight of lead and 100mg/kg body weight of moringa. Animals were sacrificed by cervical dislocation at the completion of administration and the hearts of the animals were excised and processed for histological demonstrations using the eosin and haematoxylin staining techniques. The heart tissues' homogenates were also assayed for creatinine kinase as a marker of cardiac tissue trauma. Results showed that Moringa when administered concurrently or subsequently with lead prevented to a large extent toxicological trauma and histoarchitectural disruption of the heart tissue.
Description
None
Keywords
Heart Lead toxicity, Moringa, Regenerative, Prophylactic
Citation
2. Williams, F.E., Owolabi, J.O., Ghazal, O.K. & Agunbiade, T. (2014) Rejuvenative and prophylactic effects of Moringa on lead-induced heart tissue damage in adult male Wistar Rats Models. International Journal of Moringa and Nutraceutical Research. 1(1): 93 – 98.