): Central Nervous Depressant Effect of the Glycosidic constituents of the fruits of Piper guineense.

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dc.contributor.authorWillams, F. E.
dc.contributor.authorAiyedun, J. O.
dc.contributor.authorObianwu, H. O
dc.date.accessioned2021-05-06T09:06:41Z
dc.date.available2021-05-06T09:06:41Z
dc.date.issued2016
dc.description.abstractThe central nervous system depressant effect of the butanol extract of the fruits of Piper guineense was pharmacologically screened by measuring the prolongation of barbiturate sleeping time. Nine rats (n=9) were used and assigned into three groups, with each group comprising of three rats (n=3). Group A served as the Control, while Groups B and C served as tests. Thiopentone sodium (40 mg/kg body weight) was administered subcutaneously to the rats in Group A, 2 mg/kg of the butanolic extract of the fruits of Piper guineense was administered subcutaneously to the rats in Test Group B, 30 minutes before administering same dose of thiopentone sodium, while rats in Group C received 4 mg/kg of the butanolic extract 30 minutes before administering same dose of thiopentone sodium. The sleeping time was recorded. Student-t-test at 5% significance level was used to analyze the results obtained. The mean barbiturate sleeping time prolongation of 53.67 minutes was produced by 2 mg/kg of the extract while a dose of 4 mg/kg produced mean barbiturate sleeping time prolongation of 103.67 minutes. This study suggests that the fruits of Piper guineense have central nervous system depressant effect.en_US
dc.identifier.citationWilliams et al., 2016en_US
dc.identifier.urihttp://nisebpublications.org.
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5037
dc.language.isoenen_US
dc.publisherNigerian Society for Experimental Biologyen_US
dc.relation.ispartofseriesBiokemistri.;28 (1); 34-37
dc.subjectPiper guineenseen_US
dc.subjectfruitsen_US
dc.title): Central Nervous Depressant Effect of the Glycosidic constituents of the fruits of Piper guineense.en_US
dc.typeArticleen_US

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