): Central Nervous Depressant Effect of the Glycosidic constituents of the fruits of Piper guineense.
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Nigerian Society for Experimental Biology
Abstract
The central nervous system depressant effect of the butanol extract of the fruits of Piper
guineense was pharmacologically screened by measuring the prolongation of barbiturate sleeping time. Nine rats (n=9) were used and assigned into three groups, with each group comprising of three rats (n=3). Group A served as the Control, while Groups B and C served as tests. Thiopentone sodium (40 mg/kg body weight) was administered subcutaneously to the rats in Group A, 2 mg/kg of the butanolic extract of the fruits of Piper
guineense was administered subcutaneously to the rats in Test Group B, 30 minutes before administering same dose of thiopentone sodium, while rats in Group C received 4 mg/kg of the butanolic extract 30 minutes before administering same dose of thiopentone sodium. The sleeping time was recorded. Student-t-test at 5%
significance level was used to analyze the results obtained. The mean barbiturate sleeping time prolongation of 53.67 minutes was produced by 2 mg/kg of the extract while a dose of 4 mg/kg produced mean barbiturate
sleeping time prolongation of 103.67 minutes. This study suggests that the fruits of Piper guineense have central nervous system depressant effect.
Description
Keywords
Piper guineense, fruits
Citation
Williams et al., 2016