Anti-diabetic Activity of Aqueous Extract of Senna alata (Fabacea) Flower in Alloxan-induced Diabetic Male Rats

Simple item page
dc.contributor.authorYakubu, M.T.
dc.contributor.authorUwazie, N.J.
dc.contributor.authorIgunnu, Adedoyin
dc.date.accessioned2020-05-29T15:35:49Z
dc.date.available2020-05-29T15:35:49Z
dc.date.issued2016
dc.description.abstractThis study investigated the acclaimed anti-diabetic potential of aqueous extract of Senna alata flower in alloxan-induced diabetic rats. Forty-two, male Wistar rats were randomized into six groups (I-VI) such that animals in group I which were non-diabetic received 0.5ml each of distilled water while those in groups II-IV which were induced into diabetes (intraperitoneal administration of 150 mg/kg body weight of alloxan) received orally 0.5ml each of distilled water, glibenclamide (2.5 mg/kg body weight), 25, 50 and 75mg/kg body weight of the extract respectively once daily for 13 days. The secondary metabolites in decreasing order of abundance were phenolics, flavonoids, cardiac glycosides, steroids, saponins, anthraquinones, tannins and alkaloids. The elevated (P < 0.05) blood glucose level, total cholesterol, triglycerides, low density lipoprotein-cholesterol, haemoglobin, total bilirubin, serum urea and creatinine as well as the reduced body weight, high density lipoprotein-cholesterol, liver glycogen, packed cell volume, albumin, conjugated bilirubin and hexokinase activity by the alloxan were reversed and or/ameliorated by the extract, similar to the reference drug, glibenclamide. The extract restored the alloxan treatment related distortion and atrophy in the pancreas. The available data in the study suggests that aqueous extract of Sena alata flower at the doses of 25, 50 and 75mg/kg body exhibited anti-diabetic activity with the highest dose displaying the most profound activity. The anti-diabetic activity conferred by the secondary metabolite is suggested, among other, to be via enhancing the activity of hexokinase. This study has justified the folkloric use of S. alata flower in the management of diabetes.en_US
dc.description.sponsorshipFunded by the authorsen_US
dc.identifier.urihttp://hdl.handle.net/123456789/4120
dc.language.isoenen_US
dc.publisherPublished by Cameroon Biosciences Societyen_US
dc.relation.ispartofseriesCameroon Journal of Biological and Biochemical Sciences;24: 07-17
dc.subjectAnti-diabeticen_US
dc.subjectSenna alataen_US
dc.subjectPancreasen_US
dc.subjectFabaceaeen_US
dc.subjectHexokinaseen_US
dc.titleAnti-diabetic Activity of Aqueous Extract of Senna alata (Fabacea) Flower in Alloxan-induced Diabetic Male Ratsen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Yakubu et al. 2016- CJBBS.pdf
Size:
643.56 KB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.69 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections