Sodium butyrate recovers high-fat diet-fed female Wistar rats from glucose dysmetabolism and uric acid-associated cardiac tissue damage
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Date
2019-06-29
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Publisher
Springer
Abstract
Increased global consumption of high-fat/high-calorie diet has led to higher incidence of the multifactorial cardiometabolic
syndrome especially among women. The links between glucose deregulation and eventual mortal cardiac diseases are still being
investigated. However, several reports have implicated elevated uric acid (UA) in the progression of metabolic disorders
especially during high-fructose diet. Also, butyrate (BUT) a short-chain fatty acid is being identified with intriguing therapeutic
potentials in metabolic disorders. We therefore hypothesized that high-fat diet-induced glucose deregulation and cardiac tissue
damage are associated with elevated UA and attenuated by BUT in female rats. Twenty-four 10-week-old female Wistar rats with
weights ranging from 135 to 150 g were treated with normal rat chow and distilled water (po) or sodium butyrate (200 mg/kg; po)
or high-fat diet and distilled water (po) or high-fat diet and sodium butyrate. Treatments lasted for 6 weeks. Results showed that
high-fat diet caused glucose dysmetabolism, elevated plasma triglyceride (TG), total cholesterol (TC), corticosterone,
malondialdehyde (MDA), plasma and cardiac UA, and lactate dehydrogenase (LDH). High-fat diet also led to depressed reduced
glutathione (GSH). Histological analysis of cardiac tissue showed cellular infarction, infiltration, and fibrosis in high-fat diet-fed
rats. However, all these effects were ameliorated by BUT treatment. The findings here showed that high-fat diet resulted in
glucose dysmetabolism and cardiac tissue damage through a UA-dependent mechanism and that BUT can protect against high-fat
diet-induced cardiometabolic disorders through UA suppression and augmentation of glutathione antioxidant defenses.
Description
Keywords
High-fat diet, Oxidative stress, SCFA, Sodium butyrate, Uric acid.
Citation
Badejogbin, C., Areola, D. E., Olaniyi, K. S., Adeyanju, O. A., & Adeosun, I. O. (2019). Sodium butyrate recovers high-fat diet-fed female Wistar rats from glucose dysmetabolism and uric acid-associated cardiac tissue damage. Naunyn-Schmiedeberg's archives of pharmacology, 392(11), 1411–1419. https://doi.org/10.1007/s00210-019-01679-2