Research Journal of Health Sciences

Simple item page
dc.contributor.authorOmotoso, G. O.
dc.contributor.authorKadir, R. E.
dc.contributor.authorGbadamosi, I. T.
dc.contributor.authorAkinlolu, A. A.
dc.contributor.authorAdunmo, G. O.
dc.contributor.authorKolo, R. M.
dc.contributor.authorLawal, M. O.
dc.contributor.authorAmeen, M. O.
dc.date.accessioned2019-05-06T12:28:48Z
dc.date.available2019-05-06T12:28:48Z
dc.date.issued2018-02-01
dc.description.abstractObjectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum. Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO. Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1844
dc.language.isoenen_US
dc.subjectdemyelinationen_US
dc.subjectcuprizoneen_US
dc.subjectcerebellar damageen_US
dc.subjectMoringa oleiferaen_US
dc.subjectoxidative enzymesen_US
dc.titleResearch Journal of Health Sciencesen_US
dc.title.alternativeMoringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female ratsen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2018_Res J Health Sci_6(1) 13-25_Omotoso et al_Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats.pdf
Size:
1.06 MB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.69 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections