Melatonin prevents and ameliorates lead-induced gonadotoxicity through antioxidative and hormonal mechanisms

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dc.contributor.authorLuqman Aribidesi Olayaki
dc.contributor.authorIsiaka Abdullateef Alagbonsi
dc.contributor.authorAbdulrahim Amin Halimat
dc.contributor.authorWale Johnson Adeyemi
dc.contributor.authorMuftiat Bakare
dc.contributor.authorNoah Omeiza
dc.date.accessioned2025-04-16T09:47:55Z
dc.date.available2025-04-16T09:47:55Z
dc.date.issued2018-04-03
dc.description.abstractWe investigated the effects of melatonin on sperm parameters and some biochemical markers in lead- exposed male Wistar rats. Lead (50 mg/kg bw/day) and/or melatonin (4 mg/kg or 10 mg/kg bw/day) was administered for 4 weeks, while 2-week lead exposure was preceded by or followed by 2-week treatment with both doses of melatonin in other groups. Lead reduced glutathione, catalase, adjusted testes weight, semen parameters but did not change malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase, and total antioxidant capacity. Though independent of prolactin, lead-induced gonadotoxicity was both centrally and peripherally mediated, as it reduced gonadotropin-releasing hormone and testos- terone levels, while gonadotropin levels did not change significantly probably due to negative feedback by elevated estradiol. However, pre-, simultaneous, or posttreatment of lead-exposed rats with melatonin reduced MDA, SOD, and estradiol but dose-dependently increased other parameters. Conclusively, lead causes male gonadotoxicity through oxidative stress and endocrine mechanisms, and these could be dose- dependently prevented and ameliorated by melatonin.
dc.identifier.citationGonadotoxicity, lead, melatonin, oxidative stress, reproductive hormone, sperm
dc.identifier.issn1477-0393
dc.identifier.uriDOI: 10.1177/0748233718773508
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15061
dc.language.isoen
dc.publisherTaxicology And Industrial Health
dc.relation.ispartofseries1-13
dc.titleMelatonin prevents and ameliorates lead-induced gonadotoxicity through antioxidative and hormonal mechanisms
dc.typeArticle

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