Phytochemical screening and evaluation of diuretic activity of the aqueous leaf extract of Croton zambesicus Linn. (Euphorbiaceae) in albino rats.

Simple item page
dc.contributor.authorAyanniyi, R.O
dc.contributor.authorMaiha, B.B
dc.contributor.authorBiliamin, S.A
dc.contributor.authorJimoh Akanbi, M.H
dc.date.accessioned2019-10-31T14:35:21Z
dc.date.available2019-10-31T14:35:21Z
dc.date.issued2016
dc.description.abstractBackground: Non optimal blood pressure has been reported as a leading cause of death globally. Croton zambesicus is a highly valued medicinal plant in Nigeria and the West African sub-region. It is used by traditional medicine practitioners in the management of hypertension. This study aims to determine the phytochemical constituents and evaluate the diuretic activity of the aqueous leaf extract of Croton zambesicus in albino rats. Methods: The aqueous leaf extract of Croton zambesicus was screened for phytochemical constituents. The effect of aqueous leaf extract of Croton zambesicus on urine output was evaluated and the concentration of sodium and potassium in urine was also determined. Results: Phytochemical analysis of the aqueous leaf extract revealed the presence of flavonoids, tannins, saponins, terpenoids, alkaloids and cardiac glycosides. The aqueous extract (10 mg/kg) produced significant (p<0.001) increase in urine output when compared to the control and hydrochlorothiazide (10 mg) administered groups. However, there was no significant difference (p>0.05) in Na+ and K+ concentrations of urine. The results obtained from this study revealed the aqueous leaf extract of Croton zambesicus contains bioactive constituents which includes; flavonoids, tannins, saponins, triterpenes, alkaoids and cardiac glycosides. In addition, the leaf extract produced an increase in urine output comparable to that produced by hydrochlorothiazide.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/3323
dc.language.isoenen_US
dc.publisherLibrary and Publications Committee University of Ilorinen_US
dc.subjectCroton zambesicusen_US
dc.subjectTraditional medicineen_US
dc.subjectPhytochemicalsen_US
dc.subjectHydrochlorothiazideen_US
dc.subjectDiureticen_US
dc.titlePhytochemical screening and evaluation of diuretic activity of the aqueous leaf extract of Croton zambesicus Linn. (Euphorbiaceae) in albino rats.en_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Phytochemical Screening and Diuretic Activity of Croton zambesicus.docx
Size:
158.54 KB
Format:
Microsoft Word XML
Description:
Main Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.69 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections