Double-blind randomized controlled trial comparing misoprostol and oxytocin for management of the third stage of labor in a Nigerian hospital.

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dc.contributor.authorMusa, Abdulkarim
dc.contributor.authorIjaiya, Munir'deen
dc.contributor.authorSaidu, Rakiya
dc.contributor.authorAboyeji, Abiodun
dc.contributor.authorJimoh, Abiodun
dc.contributor.authorAdesina, Kikelomo
dc.contributor.authorAbdul, Ishaq
dc.date.accessioned2019-11-14T14:00:29Z
dc.date.available2019-11-14T14:00:29Z
dc.date.issued2015
dc.description.abstractObjective: To compare the efficacy of oral misoprostol with that of oxytocin for active management of the third stage of labor (AMTSL). Methods: A double-blind randomized control trial was undertaken at a center in Ilorin, Nigeria, between January and June 2013. Every other eligible patient (in the first stage of labor at term, to have a spontaneous vaginal delivery, and no/low risk of postpartum hemorrhage [PPH]) were randomly assigned with computer-generated random numbers to receive oral misoprostol (600 μg) plus placebo injection or oral placebo plus oxytocin injection (1 mL of 10 IU) in the third stage of labor. The primary outcome was amount of blood loss during delivery. Results: Mean postpartum blood loss was 325.85 ± 164.72 mL in the 100 patients givenmisoprostol and 303.95±163.33 mL in the 100 patients given oxytocin (P=0.391). PPH(≥500mL blood loss) was recorded in 15 (15.0%) patients given misoprostol and 14 (14.0%) given oxytocin (P = 0.841). Shivering, pyrexia, and diarrhea were all significantly more common in the misoprostol group (P b 0.01 for all). Conclusion: The efficacy of oral misoprostol was similar to that of intramuscular oxytocin. Adverse effects associatedwith misoprostol were transient and self-limiting. Thus, oral misoprostol is efficacious and a good alternative to oxytocin for AMTSLen_US
dc.identifier.citationMusa, A.O, Ijaiya M.A, Saidu, R, Aboyeji, A.P, Jimoh, A.A, Adesina K.T& Abdul I.F (2015): Double-blind randomized controlled trial comparing misoprostol and oxytocin for management of the third stage of labor in a Nigerian hospital. International Journal of Gynecology & Obstetrics 129(3); 227-230.en_US
dc.identifier.urihttps://obgyn.onlinelibrary.wiley.com/doi/abs/10.1016/j.ijgo.2015.01.008
dc.identifier.urihttp://hdl.handle.net/123456789/3407
dc.language.isoenen_US
dc.publisherThe Journal of the International Federation of Obstetrics and Gynaecology (FIGO)en_US
dc.relation.ispartofseriesVol. 129;No. 3
dc.subjectAdverse effects Efficacyen_US
dc.subjectIntramuscular oxytocinen_US
dc.subjectOral misoprostolen_US
dc.subjectThird stage of laboren_US
dc.titleDouble-blind randomized controlled trial comparing misoprostol and oxytocin for management of the third stage of labor in a Nigerian hospital.en_US
dc.typeArticleen_US

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