Effect of Chronic Administration of Caffeine on Plasma Testosterone Level and Body Mass Index in Male Wistar R
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Date
2021
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Nigerian Society for Experimental Biology
Abstract
Caffeine is one of the most frequently ingested pharmacological agents contained in several
beverages and food items. With some positive biological effects on the body system, little
knowledge is known on its effect on reproductive parameters. This present study therefore aimed
to determine the effect of aqueous solution of caffeine on serum testosterone level and body mass
index (BMI) in male Wistar rats. Twenty-one (21) male Wistar rats with average weight of 250 ±
20 g were obtained for this study and randomly grouped into three (3) of seven (7) rats each. Group A, served as the control and received 0.5 ml of normal saline while groups B and C served
as test groups and received orally 0.38 mg/kg (low dose) and 1.14 mg/kg (high dose) of caffeine
respectively, once daily for 14 days. There was significant increase (p<0.05) in body weight, BMI, and plasma testosterone levels of high dose (HD) and low dose (LD) compared to the
control, while there was no significant (p>0.05) change in length of the animals compared to the
control. Long time consumption of caffeine has potential to stimulate production of testosterone
to possibly increase sex drive perhaps via hypothalamo-pituitary-testicular axis, and also increase
BMI.
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Body mass index, caffeine, testis, testosterone