Burden and outcome of respiratory morbidities among children and adolescents with sickle cell disease—A retrospective review of emergency presentations in some Nigerian tertiary institutions.

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dc.contributor.authorIbraheem, Rasheedat Mobolaji
dc.contributor.authorAbdulkadir, Mohanned Baba
dc.contributor.authorAliu, Rasaki
dc.contributor.authorIssa, Amudalat
dc.contributor.authorIbrahim Olayinka Rasheed
dc.contributor.authorBello, Abdulafeez Oyesola
dc.contributor.authorAbubakar, Fatima Ishaq
dc.contributor.authorOloyede, Precious Iso
dc.contributor.authorOlasinde, Yetunde Toyin
dc.contributor.authorBriggs, Datonye Christopher
dc.contributor.authorBashir, MuhammedFaruk
dc.contributor.authorSalau, Qassim Olakunle
dc.contributor.authorGarba, Bilkisu Ilah
dc.contributor.authorAmeen, Hafsat Abolore
dc.contributor.authorSuleiman, Mohammed Bello
dc.contributor.authorBewaji, Temitayo Olubunmi
dc.contributor.authorShina, Hassan Kamiludeen
dc.date.accessioned2025-04-30T12:55:35Z
dc.date.available2025-04-30T12:55:35Z
dc.date.issued2024-05-16
dc.description.abstractBackground Despite the huge burden of sickle cell disease (SCD) among Nigerian children, the burden and outcome of respiratory illnesses remain undocumented. Thus, we aimed to describe the spectrum and outcome of respiratory illnesses among SCD childrenand adolescentadmissions in ten Nigerian tertiary hospitals. Method A retrospective review of the SCD admission records of children and adolescents with a confirmed diagnosis of respiratory illnesses from 2012 to 2021 in ten tertiary health facilities across five geopolitical zones in Nigeria was conducted. The data, collectedbetween March and June 2023, included the age, sex, diagnosis, complications, duration and outcome of hospitalization. Results Of the 72,333 paediatric admissions, 7,256 (10.0%) had SCD; the proportion of SCD from the total admission ranged from 2.1 to 16.3% in the facilities. Of the 7,256 children and adolescents with SCD, 1,213 (16.7%) had respiratory morbidities. Lower respiratory disease was the most common (70.0%) respiratory entity and the majority were pneumonia (40.1.0%), followed by acute chest syndrome (26.7%). Seventeen (1.4%) patients died; all had lower respiratory diseases [(acute chest syndrome ACS (11, 64.7%), pneumonia; 5, 29.4%, and asthma (1, 5.9%). Based on the proportion of deaths among overall SCD, the 17 death cases contributed 9.4% (95% CI 5.9 to 14.5). Factors associated with deaths included duration of hospitalization less than 72 hours and lower respiratory tract diseases. Conclusion Sickle cell disease is a major contributor to hospitalization among Nigerian children and adolescents, with high respiratory morbidity and mortality. Pneumonia and acute chest syndrome were associated with mortality, andthe highest risk of death within the first 72 hours.
dc.identifier.citationIbraheem RM, Abdulkadir MB, Aliu R, Issa A, Ibrahim OR, Bello AO, et al. (2024) Burden and outcome of respiratory morbidities among children and adolescents with sickle cell disease—A retrospective review of emergency presentations in some Nigerian tertiary institutions. PLoS ONE 19(5): e0303323.
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0303323
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15733
dc.language.isoen
dc.publisherPublic Library of Science, United States of America
dc.relation.ispartofseriesVol 19(5); e0303323
dc.titleBurden and outcome of respiratory morbidities among children and adolescents with sickle cell disease—A retrospective review of emergency presentations in some Nigerian tertiary institutions.
dc.typeArticle

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