ARISTOLONCHIA REPENS STEM BARK AMELIORATES LIVER AND KIDNEY FUNCTION IN HIGH-FAT DIET AND STREPTOZOTOCIN-INDUCED DIABETIC RATS
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Date
2023-12
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Nigerian Society of experimental Biology.
Abstract
Aristolonchia repens, is among such herb utilized locally for managing diabetes and related problems. The study evaluated the ameliorative effects of aqueous extract of Aristolonchia repens stem bark on liver and kidney function in high-fat diet and streptozotocin-induced diabetic rats. Type 2 diabetes was induced in rats with high-fat diet and low dose of streptozotocin (35 mg/kg body weight). Non-diabetic male Wistar rats were treated with distilled water (Naïve control) while the diabetic male Wistar rats were treated with water, Metformin (100 mg/kg body weight), 50, 100 and 200 mgkg-1 bodyweight of aqueous extract of Aristolonchia repens stem bark for 28 days. The rats were sacrificed and sera were collected and analyzed. High-fat diet and streptozotocin significantly altered (P<0.05) the alanine aminotransferase, aspartate aminotransferase activities, concentration of total bilirubin, total protein, albumin, globulin, creatinine, urea, potassium, sodium, bicaronate and chloride when compared with Naïve and positive control. Wistar rats treated with 50, 100 and 200 mgkg-1 body weight of aqueous extract of Aristolonchia repens significantly did not altered (p>0.05) the alanine aminotransferase and aspartate aminotransferase activities, when compared with Naive and Metformin group. Similarly, the concentration of total bilirubin, total protein, albumin, globulin, creatinine, urea, potassium, sodium, bicaronate and chloride was not significantly altered (p>0.05) when compared with the Naïve and Metformin group. This study suggests that Aristolonchia repens stem ameliorates liver and kidney function in high-fat diet and streptozotocin-induced diabetic rats and hence may be safe for use in the management of diabetes.
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Keywords
Aristolochia repens, Diabetes Mellitus, Streptozotocin, High-fat diet