Effects of albendazole administration on the testicular histology of adult Wistar rats.
dc.contributor.author | Omotoso, Gabriel Olaiya | |
dc.contributor.author | Alabi, AS | |
dc.contributor.author | Oyabambi, AO | |
dc.date.accessioned | 2018-06-08T10:02:30Z | |
dc.date.available | 2018-06-08T10:02:30Z | |
dc.date.issued | 2013 | |
dc.description.abstract | Background: The testicular cytoarchitectural effects of albendazole administration were studied in adult Wistar rats. Materials and Methods: The animals were grouped into three groups, with six (6) rats per group. While animals in the control group A were given water, the treatment groups B and C received 15 mg/kg and 30 mg/kg respectively of albendazole orally for three consecutive days. The animals were sacrificed by cervical dislocation about 24 hours after drug administration, and the testes removed, fixed in 10% formal saline and processed for histological consideration, using Haematoxylin and Eosin stains. Results: Varying degrees of histological changes were noticed in the seminiferous tubules, which were marked in the group that received the higher dose of the drug. Conclusion: These structural distortions and degenerations of testicular tissues that occurred after albendazole administration are dose-dependent, and could affect reproductive functions in males. | en_US |
dc.identifier.citation | 12(2):50-52 | en_US |
dc.identifier.other | DOI: 10.4103/1596-2393.127957 | |
dc.identifier.uri | http://www.jecajournal.org/article.asp?issn=1596-2393;year=2013;volume=12;issue=2;spage=50;epage=52;aulast=Omotoso | |
dc.identifier.uri | http://hdl.handle.net/123456789/431 | |
dc.language.iso | en | en_US |
dc.publisher | Journal of Experimental and Clinical Anatomy | en_US |
dc.subject | Albendazole | en_US |
dc.subject | histology | en_US |
dc.subject | testes | en_US |
dc.subject | Wistar rats | en_US |
dc.title | Effects of albendazole administration on the testicular histology of adult Wistar rats. | en_US |
dc.type | Article | en_US |
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