Effects of albendazole administration on the testicular histology of adult Wistar rats.

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dc.contributor.authorOmotoso, Gabriel Olaiya
dc.contributor.authorAlabi, AS
dc.contributor.authorOyabambi, AO
dc.date.accessioned2018-06-08T10:02:30Z
dc.date.available2018-06-08T10:02:30Z
dc.date.issued2013
dc.description.abstractBackground: The testicular cytoarchitectural effects of albendazole administration were studied in adult Wistar rats. Materials and Methods: The animals were grouped into three groups, with six (6) rats per group. While animals in the control group A were given water, the treatment groups B and C received 15 mg/kg and 30 mg/kg respectively of albendazole orally for three consecutive days. The animals were sacrificed by cervical dislocation about 24 hours after drug administration, and the testes removed, fixed in 10% formal saline and processed for histological consideration, using Haematoxylin and Eosin stains. Results: Varying degrees of histological changes were noticed in the seminiferous tubules, which were marked in the group that received the higher dose of the drug. Conclusion: These structural distortions and degenerations of testicular tissues that occurred after albendazole administration are dose-dependent, and could affect reproductive functions in males.en_US
dc.identifier.citation12(2):50-52en_US
dc.identifier.otherDOI: 10.4103/1596-2393.127957
dc.identifier.urihttp://www.jecajournal.org/article.asp?issn=1596-2393;year=2013;volume=12;issue=2;spage=50;epage=52;aulast=Omotoso
dc.identifier.urihttp://hdl.handle.net/123456789/431
dc.language.isoenen_US
dc.publisherJournal of Experimental and Clinical Anatomyen_US
dc.subjectAlbendazoleen_US
dc.subjecthistologyen_US
dc.subjecttestesen_US
dc.subjectWistar ratsen_US
dc.titleEffects of albendazole administration on the testicular histology of adult Wistar rats.en_US
dc.typeArticleen_US

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