Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats

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dc.contributor.authorOmotoso G.O.
dc.contributor.authorKadir R.E.
dc.contributor.authorLewu S.F.
dc.contributor.authorGbadamosi I.T
dc.contributor.authorAkinlolu A.A.
dc.contributor.authorAdunmo G.O.
dc.contributor.authorKolo R.M.
dc.contributor.authorLawal M.O
dc.contributor.authorAmeen M.O.
dc.date.accessioned2025-05-03T15:55:37Z
dc.date.available2025-05-03T15:55:37Z
dc.date.issued2018
dc.description.abstractObjectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum. Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO. Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity. Keywords: demyelination, cuprizone, cerebellar damage, Moringa oleifera, oxidative enzymes
dc.identifier.citationdemyelination, cuprizone, cerebellar damage, Moringa oleifera, oxidative enzymes
dc.identifier.isbnhttp://dx.doi.org/10.4314/rejhs.v6i1.3
dc.identifier.urihttp://dx.doi.org/10.4314/rejhs.v6i1.3
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15942
dc.language.isoen
dc.publisherResearch Journal of Health Sciences
dc.relation.ispartofseriesVol 6(1), Jan./Mar., 2018 ; 13-25
dc.titleMoringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats
dc.typeArticle

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