In vitro Antimicrobial and in vivo Lead Acetate Poison Abatement Study of Garcinia kola Heckel
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Taibah University for Science
Abstract
The in vitro antimicrobial and in vivo heavy metal abatement properties of aqueous extracts of Garcinia kola Heckel (bitter
cola) were investigated using opportunistic pathogens and Wistar rats as experimental models. A marked inhibitory activity against
Aspergillus niger, Aspergillus flavus and Candida albicans was recorded at 100 mg/ml of the crude relative to ketoconozole and
fluconazole drugs. Similarly, different concentrations (25 mg/ml, 50 mg/ml and 100 mg/ml) of the crude extracts of bitter cola
inhibited species of Escherichia coli and Pseudomonas aeruginosa almost as effectively as the control drug of streptomycine
used. Chronic lead acetate poisoned wistar rats in groups B, C, D, E exposed to G. kola supplemented feed and water ad libitum
showed variable decrease in the serum alkaline phosphatase level while aspartate and alanine aminotransferases level reduces
in C and D groups compared to the negative control group. The kidney biomarkers; serum creatinine and urea concentrations
were not significantly different at P ≤ 0.05 for rat groups C, D, E when compared with the positive and negative control groups
respectively. Mild infiltration and cell distortion were observed in the liver and kidney sections of the rats exposed to uncoated bitter
cola supplemented feed while suggesting an overriding effect from the nut coats. The study reaffirms the medicinal potential of
coated and uncoated bitter cola to act as abatement of lead toxicity and alternative antimicrobial. Furthermore, G. kola could be a
double-edged drug for the spontaneous amelioration of lead toxicity and secondary infections due to lead poisoning
Description
Keywords
Garcinia kola, Antimicrobial, Lead abatement, Histopayhology, Opportunistic pathogens