Peptidomics screening for the discovery of uterotonic plant peptides

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dc.contributor.authorJohannes, Koehbach
dc.contributor.authorAlfred, F. Attah
dc.contributor.authorMargaret, O’Brien
dc.contributor.authorMichael, Freissmuth
dc.contributor.authorChristian, W. Gruber
dc.date.accessioned2021-12-10T12:19:14Z
dc.date.available2021-12-10T12:19:14Z
dc.date.issued2012
dc.description.abstractDrug discovery from natural products is still one of the biggest sources of novel lead compounds. In particular, plant cyclotides, disulfide-rich peptides comprising three conserved disulfide bonds in a knotted arrangement, known as cyclic cystine knot motif, and a head-to-tail cyclization, have been extensively investigated over the last four decades for their use as scaffolds in drug development. However, their distribution among flowering plants still remains limited to few species of the families of Rubiaceae (coffee), Violaceae (violet), Cucurbitaceae (cucurbit), Fabaceae (bean) and recently Solanaceae (potato family), but it is very likely that cyclotides are more widely distributed since their predicted number in Rubiaceae alone is ~50.000. Additionally, the pharmacological validation of plants used in traditional medicines may trigger the discovery of novel uterotonic compounds.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/7139
dc.language.isoenen_US
dc.publisherBMC Pharmacology and Toxicologyen_US
dc.relation.ispartofseriesVol. 13;Supp. 1
dc.subjectDrugen_US
dc.titlePeptidomics screening for the discovery of uterotonic plant peptidesen_US
dc.typeArticleen_US

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