Quality assessment of different brands of diclofenac tablets marketed in Ilorin metropolis: a pharmaceutical and public health perspective.

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dc.contributor.authorAbdullahi, S.T.
dc.contributor.authorOlanipekun, O.C.
dc.contributor.authorNjinga, N.S.,
dc.contributor.authorEniayewu, O.I.
dc.contributor.authorBamidele, O.D.
dc.contributor.authorBakare-Odunola, M.T.
dc.contributor.authorShittu, A.O.
dc.contributor.authorSoyinka, J.O.
dc.date.accessioned2024-05-13T10:51:52Z
dc.date.available2024-05-13T10:51:52Z
dc.date.issued2020
dc.description.abstractBackground: The quality of a medicinal product is an important factor for its safety and efficacy. Poor-quality medicines are a major impediment to improvements in public health. This study assessed the pharmaceutical quality of different brands of diclofenac (DCF) tablets in Ilorin metropolis. Methods: Four randomly selected brands of diclofenac potassium tablets (coded: DCF-A, DCF-B, DCF-C and DCF-D) were obtained from pharmaceutical outlets, and quality parameters were evaluated according to Pharmacopeial methods. The potency of tablets was determined spectrophotometrically based on the measurement of maximum absorbance at a wavelength of 276 nm in doubly distilled water. Results: Method validation according to the International Council for Harmonization guidelines showed acceptable sensitivity (limit of detection of 0.3886 μg/mL and limit of quanti􀃶cation of 1.1775 μg/mL), precision (% relative standard deviation range of 0.72 – 1.54), accuracy (% recovery range of 98.9 – 101.3). Average contents of active diclofenac were 45, 98, 103 and 105% for DCF-A, DCF-B, DCF-C and DCF-D respectively. DCF-A brand was not only substandard but falsi􀃶ed based on British Pharmacopoeia potency speci􀃶cation range of 95 – 105%. Conclusion: A substandard and falsi􀃶ed brand of diclofenac tablets was detected. Drug regulatory authority must ensure periodic post-registration surveillance of licensed pharmaceutical products marketed in the country to secure the health and safety of the populace.
dc.identifier.citationAbdullahi, S.T., Olanipekun, O.C., Njinga, N.S., Eniayewu, O.I., Bamidele, O.D., Bakare-Odunola, M.T., Shittu, A.O. & Soyinka, J.O. (2020). Quality assessment of different brands of diclofenac tablets marketed in Ilorin metropolis: a pharmaceutical and public health perspective. Nigerian Journal of Pharmacy. 54(2): 49-65.
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/14188
dc.language.isoen
dc.publisherNigerian Journal of Pharmacy. Published by Pharmaceutical Society of Nigeria.
dc.subjectdiclofenac tablets
dc.subjectspectrophotometric analysis
dc.subjectquality
dc.subjectsubstandard
dc.subjectfalsi􀃶ed medicines
dc.titleQuality assessment of different brands of diclofenac tablets marketed in Ilorin metropolis: a pharmaceutical and public health perspective.
dc.typeArticle

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