Mechanisms underpinning Carpolobia lutea G. Don ethanol extract’s neurorestorative and antipsychotic-like activities in an NMDA receptor antagonist model of schizophrenia

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dc.contributor.authorNoah A Omeiza
dc.contributor.authorAdewale Bakre
dc.contributor.authorBenneth Ben-Azu
dc.contributor.authorAbimbola A. Sowunmi
dc.contributor.authorAbdulrahim Halimat A
dc.contributor.authorJoseph Chimezie
dc.contributor.authorSodiq O Lawal
dc.contributor.authorOlusegun G Adebayo
dc.contributor.authorAbdullateef I Alagbonsi
dc.contributor.authorOlugbenga Akinola
dc.contributor.authorAmos O Abolaji
dc.contributor.authorAdegbuyi O. Aderibigbe
dc.date.accessioned2025-05-12T09:02:28Z
dc.date.available2025-05-12T09:02:28Z
dc.date.issued2023-01-30
dc.description.abstractEthnopharmacological relevance: Persistent ketamine insults to the central nervous system block NMDA receptors and disrupt putative neurotransmission, oxido–nitrosative, and inflammatory pathways, resulting in schizophrenia-like symptoms in animals. Previously, the ethnomedicinal benefits of Carpolobia lutea against insomnia, migraine headache, and insanity has been documented, but the mechanisms of action remain incomplete. Aim of the study: Presently, we explored the neuro-therapeutic role of Carpolobia lutea ethanol extract (C. lutea) in ketamine-induced schizophrenia-like symptoms in mice. Materials and methods: Sixty-four male Swiss (22 ± 2 g) mice were randomly assigned into eight groups (n = 8/ group) and exposed to a reversal ketamine model of schizophrenia. For 14 days, either distilled water (10 mL/kg; p.o.) or ketamine (20 mg/kg; i.p.) was administered, following possible reversal treatments with C. lutea (100, 200, 400, and 800 mg/kg; p.o.), haloperidol (1 mg/kg, p.o.), or clozapine (5 mg/kg; p.o.) beginning on days 8–14. During the experiment, a battery of behavioral characterizations defining schizophrenia-like symptoms were obtained using ANY-maze software, followed by neurochemical, oxido-inflammatory and histological as- sessments in the mice brains. Results: A 7-day reversal treatment with C. lutea reversed predictors of positive, negative and cognitive symptoms of schizophrenia. C. lutea also mitigated ketamine-induced neurochemical derangements as evidenced by mod- ulations of dopamine, glutamate, norepinephrine and serotonin neurotransmission. Also, the increased acetyl- cholinesterase activity, malondialdehyde nitrite, interleukin-6 and tumor necrosis-factor-α concentrations were reversed by C. lutea accompanied with elevated levels of catalase, superoxide dismutase and reduced glutathione. Furthermore, C. lutea reversed ketamine-induced neuronal alterations in the prefrontal cortex, hippocampus and cerebellum sections of the brain. Conclusion: These findings suggest that C. lutea reverses the cardinal symptoms of ketamine-induced schizo- phrenia in a dose-dependent fashion by modulating the oxido-inflammatory and neurotransmitter-related mechanisms.
dc.identifier.citationAntipsychotics C. lutea Ketamine Neurotransmitters Oxido-inflammation Schizophrenia
dc.identifier.urihttps://doi.org/10.1016/j.jep.2022.115767
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16680
dc.language.isoen
dc.publisherJournal of Ethnopharmacology
dc.relation.ispartofseriesVolume 301,; 1-19
dc.titleMechanisms underpinning Carpolobia lutea G. Don ethanol extract’s neurorestorative and antipsychotic-like activities in an NMDA receptor antagonist model of schizophrenia
dc.typeArticle

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