Anti-inflammatory and bronchodilatory constituents of leaf extracts of Anacardium occidentale L. in animal models

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dc.contributor.authorAwakan, J.O.
dc.contributor.authorMalomo, S.O.
dc.contributor.authorAdejare, A.A.
dc.contributor.authorIgunnu, Adedoyin
dc.contributor.authorAtolani, O.
dc.contributor.authorAdebayo, A.H.
dc.contributor.authorOwoyele, B.V.
dc.date.accessioned2020-05-22T22:15:32Z
dc.date.available2020-05-22T22:15:32Z
dc.date.issued2017
dc.description.abstractObjective: Anacardium occidentale L. leaf is useful in the treatment of inflammation and asthma, but the bioactive constituents responsible for these activities have not been characterized. Therefore, this study was aimed at identifying the bioactive constituent(s) of A. occidentale ethanolic leaf extract (AOEL) and its solvent-soluble portions, and evaluating their effects on histamine-induced paw edema and bronchoconstriction. Methods: The bronchodilatory effect was determined by measuring the percentage protection provided by plant extracts in the histamine-induced bronchoconstriction model in guinea pigs. The antiinflammatory effect of the extracts on histamine-induced paw edema in rats was determined by measuring the increase in paw diameter, after which the percent edema inhibition was calculated. The extracts were analyzed using gas chromatography-mass spectrometry to identify the bioactive constituents. Column chromatography and Fourier transform infrared spectroscopy were used respectively to isolate and characterize the constituents. The bronchodilatory and anti-inflammatory activities of the isolated bioactive constituent were evaluated. Results: Histamine induced bronchoconstriction in the guinea pigs and edema in the rat paw. AOEL, hexane-soluble portion of AOEL, ethyl acetate-soluble portion of AOEL, and chloroform-soluble portion of AOEL significantly increased bronchodilatory and anti-inflammatory activities (P < 0.05). Oleamide (9-octadecenamide) was identified as the most abundant compound in the extracts and was isolated. Oleamide significantly increased bronchodilatory and anti-inflammatory activities by 32.97% and 98.41%, respectively (P < 0.05). Conclusion: These results indicate that oleamide is one of the bioactive constituents responsible for the bronchodilatory and anti-inflammatory activity of A. occidentale leaf, and can therefore be employed in the management of bronchoconstriction and inflammation.en_US
dc.description.sponsorshipFunded by the authors.en_US
dc.identifier.urihttps://doi.org/10.1016/j.joim.2017.12.009
dc.identifier.urihttp://hdl.handle.net/123456789/3955
dc.language.isoenen_US
dc.publisherElsevier Limited, Oxford, UK, for Shanghai Association of Integrative Medicine and Shanghai Changhai Hospital, China.en_US
dc.relation.ispartofseriesJournal of Integrative Medicine;
dc.subjectAnacardium occidentale L.en_US
dc.subjectBioactive constituenten_US
dc.subjectOleamideen_US
dc.subjectBronchodilatoryen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAsthmaen_US
dc.titleAnti-inflammatory and bronchodilatory constituents of leaf extracts of Anacardium occidentale L. in animal modelsen_US
dc.typeArticleen_US

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