Protective Effect of Nigella sativa (black caraway) oil on oral dichlorvos induced hematological, renal and nonspecific immune system toxicity in wistar rats

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dc.contributor.authorAdana, M. Y.
dc.contributor.authorAjao M. S.
dc.contributor.authorSansa A. B.
dc.contributor.authorImam A.
dc.contributor.authorIbrahim A.
dc.contributor.authorAlli-Oluwafuyi A.
dc.contributor.authorKareem S.B.
dc.date.accessioned2025-05-22T14:00:03Z
dc.date.available2025-05-22T14:00:03Z
dc.date.issued2017
dc.description.abstractBackground: Exposure to environmental toxins such as organophosphates poses a great threat to the health of the public. In this work, we investigated the effects of continuous exposure to dichlorvos (DDVP) on kidney function and hematological parameters, and the possible antidote activity of Nigella sativa oil (NSO). Methods: This research was conducted in 2016, at The Animal Holding and Research Laboratory of Faculty Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria. Twenty-four Wistar rats were randomly divided into four groups, six rats each. The four groups received: 1. phosphate buffer solution as controls, 2. DDVP, 3. DDVP+NSO and 4. NSO alone. After 2 wk of treatment, blood samples were collected and hematological profile (RBC, Hb), erythrocyte indices (MCV, MCH, MCHC, and Plt), renal function parameters (albumin, urea, total protein, chloride, sodium, and potassium ions) and nonspecific immune response (WBC) were measured. Results: Rat exposed to DDVP showed red blood cell count, hemoglobin, packed cell volume, albumin, and total protein levels was reduced from control, while white blood cell count and urea significantly increased as compared to controls, the change in K+ level was not significant. NSO maintained optimal levels of red blood cell count, hemoglobin, packed cell volume, albumin, white blood cell count, and urea, indicative of its protective effect against hemo-, immuno- and nephrotoxicity of DDVP. Conclusion: N. sativa (Black Caraway) oil might be a potential antidote in hematotoxicity, immunosuppression and renal dysfunction in organophosphate poisoning, especially dichlorvos. The protective effect of NSO against dichlorvos toxicity can be attributed to its antioxidant capacity.
dc.identifier.citationAjao M. S., Sansa A. B., Imam A., Ibrahim A., Adana M.Y., Alli-Oluwafuyi A., Kareem S.B. (2017) Protective Effect of Nigella sativa (black caraway) oil on oral dichlorvos induced hematological, renal and nonspecific immune system toxicity in wistar rats. Iranian Journal of Toxicology. 11(6), 1-5. Published by the Arak University of Medical Sciences and Iranian Society of Toxicology, Available online at https://ijt.arakmu.ac.ir/browse.php?mag_id=48&slc_lang=en&sid=1 (Scopus indexed, Q4)
dc.identifier.issn2251-9459
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16792
dc.language.isoen
dc.publisherArak University of Medical Sciences and Iranian Society of Toxicology
dc.subjectanemia
dc.subjectdichlorvos
dc.subjectkidney function tests
dc.subjectNigella sativa
dc.subjectorganophosphates
dc.subjectorganophosphate poisoning
dc.titleProtective Effect of Nigella sativa (black caraway) oil on oral dichlorvos induced hematological, renal and nonspecific immune system toxicity in wistar rats
dc.typeArticle

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