Evaluation of anti nociceptive and anti inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth

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dc.contributor.authorAyanniyi, Rashidat Oluwafunke
dc.contributor.authorOjuade, Fatimoh Idowu
dc.contributor.authorOlumoh-Abdul, Hidayah
dc.contributor.authorSalawu, Kayode Muritala
dc.contributor.authorOlufadi-Ahmed, , Haishat
dc.contributor.authorAdebisi-jose, Gbemisola Olusayo
dc.date.accessioned2023-04-26T11:19:02Z
dc.date.available2023-04-26T11:19:02Z
dc.date.issued2019-02
dc.description.abstractAbstract : The leaf extract of Turraea vogelii Hook. f. ex. Benth . is used in ethnomedicine for the management of pain and inflammation. Anti nociceptive activity was determined using acetic acid induced mouse writhing model. The anti inflammatory activity was investigated using in vitro bovine serum albumin (BSA) denat uration assay and BSA induced hind paw edema in rats. The extract (125 500 mg/kg) administered via the oral route produced a significant ( p <0.005) inhibition of acetic acid induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and dicl ofenac (1 0 mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10 6 1.0 µg /mL) inhibited protein denaturation with IC 50 values of ( 1.06 × 10 3 µg/mL and 2.58 × 10 3 µg/mL) for extract and diclofenac respectively. Furthermore, the leaf extract (62. 5 mg/kg) significantly (p<0.05) inhibited BSA induced paw edema in rats. The methanol leaf extract of T. vogelii has anti nociceptive and anti inflammatory activities. These findings justify the use of the plant in traditional medicine for the management o f pain and inflammation.en_US
dc.identifier.issn1011-601X
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/9297
dc.language.isoenen_US
dc.publisherThe Faculty of Pharmacy, University of Karachien_US
dc.subjectAnti nociceptive, anti inflammatory, acetic acid, bovine ser um albumin, Turraea vogellien_US
dc.titleEvaluation of anti nociceptive and anti inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benthen_US
dc.typeArticleen_US

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