Dexamethasone-induced stress exacerbates shedding, tissue antigen distribution, and pathology of caprine Brucellosis

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dc.contributor.authorTANKO, POLYCARP
dc.contributor.authorSABRI, M.Y.
dc.contributor.authorEMIKPE, B.O.
dc.contributor.authorONILUDE, O.M.
dc.contributor.authorAJADI, A.A.
dc.date.accessioned2024-04-22T10:23:48Z
dc.date.available2024-04-22T10:23:48Z
dc.date.issued2021-02-12
dc.description.abstractThis study investigated dexamethasone-treatment, shedding routes, tissue antigen distribution, and pathology of caprine Brucellosis. Eighteen non-pregnant goats were randomly grouped into A, B, and C. Group A was administered dexametha- sone for 7 days at 2 mg/kg before inoculating 0.5 mL B. melitensis at 107 CFU ocularly while group B was inoculated 0.5 mL B. melitensis only, and C as control negative. Blood samples, ocular, nasal, and vaginal swabs were obtained for evaluation. Three goats were sacrificed from each group at days 21 and 42 post-inoculation (pi) and selected tissues col- lected for PCR, histopathology, and immunohistochemistry. Brucella melitensis was detected in the ocular swabs of group A significantly higher than group B. Shedding was prolonged in group A compared to B. The overall shedding was 22.2% in group A and 9.4% in group B. The uterus of both groups A and B revealed mild inflammation and microgranuloma, extensive necrotic lesions in lymph nodes. Liver showed multi- focal necrosis predominantly in group A. Lesion scoring showed significantly higher scores in A compared to B. Strong immu- nostaining was observed in the liver, lungs, and spleen, predo- minantly at day 21 pi. This study demonstrated dexamethasone prolonged shedding, tissue antigen distribution, and pathology in dexamethasone-treated goats.
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/12424
dc.language.isoen
dc.publisherTAYLOR & FRANCIS
dc.subjectBrucellosis
dc.subjectdexamethasone
dc.subjectgoats
dc.subjectimmunohistochemistry
dc.subjecttissue antigen distribution
dc.titleDexamethasone-induced stress exacerbates shedding, tissue antigen distribution, and pathology of caprine Brucellosis
dc.typeArticle

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