Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies

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dc.contributor.authorScarfe, Lauren
dc.contributor.authorBrillant, Nathalie
dc.contributor.authorKumar, Dinesh
dc.contributor.authorAli, Noura
dc.contributor.authorAlrumayh, Ahmed
dc.contributor.authorAmali, Mohammed
dc.contributor.authorBarbellion, Stephanie
dc.contributor.authorJones, Vendula
dc.contributor.authorNiemeijer, Marije
dc.contributor.authorGoldring, Chris E.P
dc.contributor.authorPark, B. kevin
dc.contributor.authoret.al
dc.date.accessioned2021-05-27T13:03:09Z
dc.date.available2021-05-27T13:03:09Z
dc.date.issued2017
dc.description.abstractRegenerative medicine therapies hold enormous potential for a variety of currently incurable conditions with high unmet clinical need. Most progress in this field to date has been achieved with cell-based regenerative medicine therapies, with over a thousand clinical trials performed up to 2015. However, lack of adequate safety and efficacy data is currently limiting wider uptake of these therapies. To facilitate clinical translation, non-invasive in vivo imaging technologies that enable careful evaluation and characterisation of the administered cells and their effects on host tissues are critically required to evaluate their safety and efficacy in relevant preclinical models. This article reviews the most common imaging technologies available and how they can be applied to regenerative medicine research. We cover details of how each technology works, which cell labels are most appropriate for different applications, and the value of multi-modal imaging approaches to gain a comprehensive understanding of the responses to cell therapy in vivoen_US
dc.description.sponsorshipThe article was supported by the SafeSciMET programme, a European Community project under the Innovative Medicines Initiative Programme through Grant Agreement 115012. Additional support was provided by the UK Regenerative Medicine Platform (UKRMP) hub.en_US
dc.identifier.otherdoi:10.1038/s41536-017-0029-9
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5572
dc.language.isoenen_US
dc.publisherNature Regenerative Medicineen_US
dc.subjectStem cellen_US
dc.subjectRegenerative medicineen_US
dc.subjectDrug safetyen_US
dc.subjectImagingen_US
dc.titlePreclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapiesen_US
dc.typeArticleen_US

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