Blighia sapida; The Plant and Its Hypoglycins an Overview.

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dc.contributor.authorAtolani, O
dc.contributor.authorOlatunji, G.A
dc.contributor.authorFabiyi, O.A
dc.date.accessioned2023-06-13T09:19:47Z
dc.date.available2023-06-13T09:19:47Z
dc.date.issued2009
dc.descriptionPlant Reviewen_US
dc.description.abstractBlighia sapida g; family Sapindaceae is a multi purpose medicinal plant popular in the western Africa. It is well known for its food value and its poisonous chemical contents being hypoglycins A& B (unusual amino acids.) The hypoglycin Ais more available in the fruit than hypoglycin B. Hypoglycin A have been used as glucose inhibitor therapy, thereby giving room for the plant to be used for orthodox medicinal purposes in future. Its other therapeutic values have been reported as well. The ingestion of hypoglycin A forms a metabolite called methylenecyclopropane acetyl CoA (MCPACoA) which inhibit several enzymes A dehydrogenases which are essential for gluconeogenesis. This review covers history, description, origin and uses of Blighia sapida with emphasy on the fruit and its associated biologically active component (hypoglycins) and tries to show why the plant can be used as the sources of many potential drugs in treatment of diseases, especially glucose related ones. The mechanism of hypoglycin A metabolism is also explained. The hypoglycin A potential glucosesuppressing activities warranted further studies for the development of new anti-diabetes drugs with improved therapeutic valuesen_US
dc.description.sponsorshipNoneen_US
dc.identifier.citationAtolani, O., Olatunji, G. A. and Fabiyi, O. A. (2009). Blighia sapida; The Plant and Its Hypoglycins an Overview. Journal of Scientific Research 39 (2): 15-25.en_US
dc.identifier.issn0555
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/11072
dc.language.isoenen_US
dc.publisherJournal of Scientific Research ,Institute of Chemistry, University of The Punjabi Pakistanen_US
dc.relation.ispartofseries39;(2): 15-25.
dc.subjectBlighia sapida; Sapindaceae; hypoglycins; dehydrogenases; metabolismen_US
dc.titleBlighia sapida; The Plant and Its Hypoglycins an Overview.en_US
dc.typeArticleen_US

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