Determination of Normal and Variant Hemoglobin using Capillary Electrophoresis among Voluntary Blood Donors in North Central Nigeria: Implications on Blood Transfusion Services

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dc.contributor.authorDurotoye, I. A.
dc.contributor.authorSalaudeen, A. G.
dc.contributor.authorSanni, E. O.
dc.contributor.authorBabatunde, A. S.
dc.contributor.authorDurowade, A. K.
dc.contributor.authorOlawumi, H. O.
dc.contributor.authorAkande, T. M.
dc.contributor.authorMusa, O. I.
dc.date.accessioned2021-06-04T09:06:09Z
dc.date.available2021-06-04T09:06:09Z
dc.date.issued2021
dc.description.abstractAbstract Background: Voluntary non-remunerated blood donation is a strategy adopted by World Health Organization aimed at ensuring safety and adequacy of blood supply. Sub-Saharan Africa has a high prevalence of hemoglobin disorders and therefore needs to adopt stringent measures in donor selection to ensure safety for the recipient of blood transfusion. This study aimed to analyze normal and variant hemoglobin among voluntary blood donors. Methods: In this descriptive cross-sectional study, 100 prospective blood donors including 55 (55%) males and 45 (45%) females, aged 18–34 years were recruited. Capillary electrophoresis using the Minicap system was used for determining the hemoglobin variants in alkaline buffer (PH 9.4). Data analysis was done using SPSS version 20 and p-value < 0.05 was considered as the level of significance Results: The mean age of the participants was 22.23 ± 3.3 SD years. The proportion of participants with genotype AA was 67 (67%), those with AS were 17 (22 %), while those with AC were 11 (11 %). While Hb A ≥ 90% was noted in 67 (67%) blood donors, Hb S was seen in 22 (22%) and Hb A2 > 3.5% in 57 (57%). Hb F > 2% was observed in 3% of the studied participants Conclusion: Variant hemoglobin is common among blood donors and this should be taken into consideration whenever blood is being crossmatched for recipients of blood transfusion. Data from this study will be useful in raising awareness and genetic counseling.en_US
dc.identifier.citationDurotoye, A. I., Salaudeen, A. G., Sanni, E. O., Babatunde, A. S., Durowade, A. K., Olawumi, H. O., Akande, T. M., & Musa, O. I. (2021). Determination of Normal and Variant Hemoglobin using Capillary Electrophoresis among Voluntary Blood Donors in North Central Nigeria: Implications on Blood Transfusion Services. Sudan Journal of Medical Sciences (SJMS), 16(1), 33-42en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5909
dc.language.isoenen_US
dc.publisherFaculty of Medicine and Health Sciences - Omdurman Islamic Universityen_US
dc.subjectprevalenceen_US
dc.subjecthemoglobin variantsen_US
dc.subjectcapillary electrophoresisen_US
dc.titleDetermination of Normal and Variant Hemoglobin using Capillary Electrophoresis among Voluntary Blood Donors in North Central Nigeria: Implications on Blood Transfusion Servicesen_US
dc.typeArticleen_US

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