Anti-plasmodial activity of sodium acetate in Plasmodium berghei-infected mice

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dc.contributor.authorAbdulkareem, A.O
dc.contributor.authorBabamale, O.A
dc.contributor.authorOwolusi, L.O
dc.contributor.authorBusari, S.A
dc.contributor.authorOlatunji, L.A
dc.date.accessioned2023-04-03T07:34:05Z
dc.date.available2023-04-03T07:34:05Z
dc.date.issued2018-04-10
dc.description.abstractBackground: Continuous increase in drug resistance has hindered the control of malaria infection and resulted in multi-drug-resistant parasite strains. This, therefore, intensifies the search for alternative treatments with no or less side effects. Several histone deacetylase inhibitors have been characterised to possess anti-malaria activity; however, their further development as anti-malaria agents has not recorded much success. The present study investigated the anti-plasmodial activity of sodium acetate in Plasmodium berghei-infected mice, aiming at finding a better alternative source of malaria chemotherapy. Methods: Thirty female Swiss albino mice were randomly distributed into six groups. Groups A (uninfected control) and B (infected control) received only distilled water. Group C (artesunate control) were infected and treated orally with 4 mg/kg artesunate on the first day, and subsequently 2 mg/kg artesunate. Groups D, E and F were infected and orally treated with 50, 100 and 200 mg/kg sodium acetate, respectively. Results: Sodium acetate significantly lowered parasitaemia (p < 0.05) after 4 days post-treatment, and the parasite inhibition rate of 68.5% at 50 mg/kg compared favourably with the 73.3% rate of artesunate. Similarly, administration of 50 mg/kg sodium acetate improved serum total cholesterol relatively better than artesunate. Our results also revealed that sodium acetate does not interfere with liver function, as there was no significant difference (p > 0.05) in the serum activities of aspartate aminotransferase and alanine aminotransferase in both infected treated and uninfected mice. Conclusions: This study shows that sodium acetate may be a safe alternative source of anti-malaria drugs. Its effect on the serum total cholesterol also predicts its ability in correcting malaria-induced metabolic syndromes.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/8968
dc.publisherDE GRUYTERen_US
dc.subjectanti-plasmodialen_US
dc.subjectHDACIsen_US
dc.subjectmalariaen_US
dc.subjectPlasmodium bergheien_US
dc.subjectsodium acetateen_US
dc.titleAnti-plasmodial activity of sodium acetate in Plasmodium berghei-infected miceen_US
dc.typeArticleen_US

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