Evaluation of Beilschmiedia Seed Gum as a Tablet Binder
No Thumbnail Available
Date
2009
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Shagamu, Ogun State, Nigeria
Abstract
Beilschmiedia gum derived from the edible seeds of Beilschemiedia mannii (family
Lauraceae) was evaluated for its binding properties at a concentration range of 0.5-
10 % w/w in paracetamol tablets with official gelatin as a control. A comparative
analysis showed that the granules bound with Beilschmiedia gum were relatively
bigger and harder than the ones obtained with gelatin gum. The hardness,
disintegration time and dissolution rate increased with increase in concentration of
Beilschmiedia gum. Tablets containing 5 % w/w of Beilschmiedia gum had a binding
capacity approximately twice that of gelatin with a dissolution rate of 91 % after 30
min. The results obtained suggest that Beilschmiedia gum possesses potential as a
commercial binding agent
Description
Keywords
Beilschmiedia gum, gelatin, isintegration, dissolution, hardness