Antihypertensive Potential of Azadirachta indica Methanolic Leaf Extract in Salt-induced Hypertensive Rat Model

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dc.contributor.authorLawal Abubakar Zubair
dc.contributor.authorIbrahim Munirudeen
dc.contributor.authorOluseyi Omotayo Divine
dc.contributor.authorOlalekan Salaudeen Fatai
dc.contributor.authorSaka Saheed Olanrewaju
dc.contributor.authorAina Kareem Mutiat
dc.contributor.authorOlorukooba Halima Omolara
dc.contributor.authorOludele Oriire
dc.contributor.authorAbdulraheem Hamzat
dc.contributor.authorDavid Kehinde Busuyi
dc.contributor.authorFolorunso Kolade Pelumi Idunnuoluwa
dc.contributor.authorJimoh-Abdulghaffaar Hidaayah Oluwamayowa
dc.date.accessioned2025-05-07T14:03:42Z
dc.date.available2025-05-07T14:03:42Z
dc.date.issued2025-02-09
dc.description.abstractHypertension is a condition arising from persistently elevated blood pressure, leading to severe complications, including death. Factors such as high salt consumption and family history predispose individuals to hypertension. Azadirachta indica (AI) has shown potential in reducing high blood pressure, irregular heart rhythms, and abnormal heartbeats. This study aimed to assess the antihypertensive effect of Azadirachta indica methanolic leaf extract (AIMLE) on salt-induced hypertension in albino rats. The study involved 25 healthy male albino rats (150 - 250g), divided into five groups (A-E, n=5). Group A received normal salt feed and water (vehicle), group B received high-salt feed (HSF), group C received HSF and 500 mg/kg AIMLE, group D received HSF and 1000 mg/kg AIMLE, and group E received HSF and 10 mg/kg Nifedipine. Systolic (SBP) and diastolic (DBP) blood pressures were measured using the tail cuff method. Antidiuretic hormone (ADH) and Angiotensin-Converting Enzyme (ACE) levels were analyzed using ELISA methods. Nitric Oxide, Potassium, Bicarbonate, and Sodium were assayed using the colorimetric method. Administration of HSF caused a significant (p <0.05) progressive increase in SBP and DBP after 8 weeks when compared with the normal control. However, treatment with the serial doses of AIMLE resulted in a significant (p <0.05) dose dependent decrease in SBP, DBP and serum nitric oxide concentrations as well as decrease in serum levels of ACE, ADH, potassium, bicarbonate, and sodium ions when compared with untreated HSF group, after 8 weeks. These findings suggest that Azadirachta indica leaf extract may offer a natural remedy for managing hypertension.
dc.identifier.citationAzadirachta indica, ADH, Salt-induced hypertension, Antidiuretic, ACE
dc.identifier.urihttps://www.asn-ng.com/journal/article/1744788505
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16370
dc.language.isoen
dc.publisherAnatomical Society of Nigeria
dc.relation.ispartofseriesVolume 16 No. 1; 257-267
dc.titleAntihypertensive Potential of Azadirachta indica Methanolic Leaf Extract in Salt-induced Hypertensive Rat Model
dc.typeArticle

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