Co-administration of iron sulphate and nitroglycerin promoted oxidative stress and mild tissue damage in Wistar rats

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dc.contributor.authorAdeyemi, O.S
dc.contributor.authorSulaiman, F.A
dc.date.accessioned2020-01-24T12:09:50Z
dc.date.available2020-01-24T12:09:50Z
dc.date.issued2014
dc.descriptionIn this research, we present evidence that individual or co-administration of FeSO4 or NGC promoted the generation of free radical species which might have caused the tissue damage observed.en_US
dc.description.abstractThere is no clear-cut understanding yet of the effect of a sustained production of nitric oxide (NO) either through endogenous or exogenous source on the iron (Fe) metabolism in living cells. Albeit, there are evidences linking decreased NO production to increased iron levels. A high level of free iron in living cells, predispose such systems to oxidative damage through the promotion of free hydroxyl radical generation. On the other hand, a continuous and sustained high level of NO could contribute to cellular damage arising from the debilitating effect of peroxynitrite, a very reactive free radical formed between free NO and superoxide anion. This study investigated the biochemical influence of individual or co-administration of two drugs; nitroglycerin (NGC) and ferrous sulphate (FeSO4) in rats. Data revealed elevated levels of alanine transaminase, aspartate transaminase, and alkaline phosphatase as well as high malondialdehyde concentrations. Consequently, the levels of superoxide dismutase and catalase were raised. The histopathological presentations show the presence of gradual and subtle cellular damage. We present evidence that individual or co-administration of FeSO4 or NGC promoted the generation of free radical species which might have caused the tissue damage observed.en_US
dc.identifier.citationAdeyemi, O. S. & Sulaiman, F. A. (2014): Co-administration of iron sulphate and nitroglycerin promoted oxidative stress and mild tissue damage in Wistar rats. Comparative Clinical Pathology (Springer-Verlag London, UK) (2014). 23(5): 1525-1533. Doi 10.1007/s00580-013-1817-2. Published by Springer, Journal is based in U.K. www.sciencedirect.com (Springer; ISI/SCOPUS)en_US
dc.identifier.issn1618-5641
dc.identifier.urihttp://hdl.handle.net/123456789/3564
dc.language.isoen_USen_US
dc.publisherComparative Clinical Pathology (Springer-Verlag London, UK)en_US
dc.subjectLipid peroxidationen_US
dc.subjectPathologyen_US
dc.subjectMarker enzymesen_US
dc.subjectFree radicalen_US
dc.subjectDrug interactionen_US
dc.titleCo-administration of iron sulphate and nitroglycerin promoted oxidative stress and mild tissue damage in Wistar ratsen_US
dc.typeArticleen_US

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