Effects of Selected Aqueous Plant Extracts on Heamatological Parameters Plasmodium berghei Infected Mice
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Date
2016
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Faculty of Physical Sciences and Faculty of Life Sciences, University of Ilorin
Abstract
Cymbopogon citrates leaves, Khaya senagalesis stem bark, Parquetina nigrescens leaves, Psidium guajava leaves, Terminalia glaucescens stem bark and Zingiber officinale rhizome are used traditionally to treat malaria. This study evaluate the effects of the aqueous extracts of C. citrates leaves, K. senagalesis stem bark, P. nigrescens leaves, P.guajava, T. glaucescens stem bark and Z. officinale rhizome respectively on the heamatological status of NK 65 Plasmodium berghei (chloroquine sensitive parasite) infected mice. Fourty five (45) albino mice with average weight 25.5 ± 1.45g were randomly grouped into nine (9). Mice in group A serve as control not infected. Groups B, C, D, E, F, G, H and I were inoculated intraperitoneally with P. berghei. Groups C, D, E, F, G, H and I were treated with 5 mg/kg body weight of chloroquine, 200mg/kg body weight of C. citrates, K. senagalesis, P. nigrescens, P. guajava, T. glaucescens and Z. officinale aqueous extracts respectively. On day 5, red blood cell count (RBC), white blood cell count (WBC), packed cell volume, haemoglobin count (Hb), lymphocyte and neutrophil counts were assessed. There were significant (p<0.05) increase in the Hb count, RBC and PCV levels of the extract treated P. berghei infected mice in each group when compared with the untreated P. berghei infected mice. In the extracts treated infected mice, lymphocyte count was significantly (p<0.05) increased with concomitant decrease in neutrophil count. Our Findings show that all the extracts used has antianaemic properties and anti-inflammatory potential with extracts of P. nigrescens, P. guajava, T. glaucescens and Z. officinale demonstrating higher potential.
Keywords: Cymbopogon citrates, Khaya senagalesis, Parquetina nigrescens, Psidium guajava, Terminalia glaucescens, Zingiber officinale, Plasmodium berghei, anti-anaemic properties.