HONEY IMPROVES RADIOGRAPHIC FEATURES OF MONOSODIUM IODOACETATE-INDUCED STIFLE (KNEE) JOINT OSTEOARTHRITIS IN A RAT MODEL
| dc.contributor.author | Jimoh-Abdulghaffaar Hidaayah Oluwamayowa | |
| dc.contributor.author | Obalowu Abdulrauf M. | |
| dc.contributor.author | Aliyu Abdullahi | |
| dc.contributor.author | Jimoh Olanrewaju Saheed | |
| dc.contributor.author | Owoyele Bamidele Victor | |
| dc.date.accessioned | 2025-05-07T14:20:48Z | |
| dc.date.available | 2025-05-07T14:20:48Z | |
| dc.date.issued | 2022-06 | |
| dc.description.abstract | Osteoarthritis (OA) is the most common form of joint disease with over half of all people older than 65 years demonstrating radiographic changes of osteoarthritis in the knees. Honey is known to contain bioactive compounds that exert chondroprotective effects by counteracting the homeostatic dysregulation of the joint. However, its effect on the radiographic features of osteoarthritis has not been proven. This study was carried out to evaluate the effect of honey on radiographic features of monosodium iodoacetate (MIA)- induced knee osteoarthritis in female Wistar rats. Thirty female Wistar rats were randomly divided into five groups of six animals each. Animals in group one were healthy (control) rats, while animals in groups two to five were subjected to experimental osteoarthritis of the right knee joint induced by a single intra-articular injection of 1mg of MIA. The animals in groups two, three, four, and five were treated with normal saline (1ml/kg b. w.), arthocare (glucosamine/chondroitin sulfate 6.67/8.33mg/kg b. w.), low dose honey (250mg/kg b. w.) and high dose honey (1,000mg/kg b. w.) respectively. All treatments were administered orally once daily using an oral cannula for twenty-one days. All animals were subjected to radiographic assessment of the right knee joint before and after induction of OA, and after treatment. High and low-dose honey reversed the loss of joint space; sclerosis of the tibial plateau, medial, and lateral femoral condyles, when compared to the arthocare-treated and untreated groups. In conclusion, honey improved radiographic features of knee osteoarthritis in a rat model induced by monosodium iodoacetate. | |
| dc.identifier.citation | Honey, Monosodium iodoacetate, Osteoarthritis, Radiography, Rat. | |
| dc.identifier.issn | 0331-3026 | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/123456789/16391 | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | Vol 43 issue 2; 66 - 80 | |
| dc.title | HONEY IMPROVES RADIOGRAPHIC FEATURES OF MONOSODIUM IODOACETATE-INDUCED STIFLE (KNEE) JOINT OSTEOARTHRITIS IN A RAT MODEL | |
| dc.type | Article |