Glucoregulatory effect of butyrate is associated with elevated circulating VEGF and reduced cardiac lactate in high fructose fed rats
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Date
2023
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Publisher
Elsevier Science
Abstract
Background: High fructose diet has been linked with impaired body metabolism and cardiovascular
diseases. Sodium butyrate (NaB) was documented to improve glucoregulation and cardiometabolic
problems associated with high fructose diet (HFrD) but the mechanisms behind it
are unclear. As a result, the purpose of this study was to look into the effects of NaB on VEGF and
cardiac lactate in HFrD-induced dysmetabolism.
Methods: Twenty male Wistar rats of weight 130–140 g were assigned randomly after a week of
acclimation into four groups: Control diet (CTR), High fructose drink (HFrD); 10 % (w/v), NaB
(200 mg/kg bw), and HFrD + NaB (200 mg/kg bw). The animals were induced to be unconscious
with 50 mg/kg of pentobarbital sodium intraperitoneally, blood samples were taken via cardiac
puncture and cardiac tissue homogenates were obtained for Fasting Blood Sugar (FBS) and
plasma insulin, cardiac glycogen, plasma and cardiac glycogen synthase, plasma and cardiac
nitric oxide as well as vascular endothelial growth factor (VEGF).
Result: HFrD resulted in statistical elevation body and cardiac weight, plasma glucose, plasma insulin, cardiac lactate, glycogen and decreased nitric oxide level (NO) when compared with the control group. Administration of NaB reduced cardiac weight, blood glucose, plasma insulin, cardiac lactate while nitric oxide and glycogen increased (P < 0.05). NaB increased plasma glycogen synthase in normal rats, plasma and cardiac circulating VEGF in HFrD administered rats
(P < 0.05) while no change was produced in plasma and cardiac glycogen synthase level of HFrD
treated rats.
Conclusion: Sodium butyrate improves glucoregulation by reducing cardiac lactate and increasing
circulating VEGF in HFrD-treated rats.
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Keywords
Sodium butyrate HiSodium butyrate High fructose drink Glucoregulation Vascular endothelial growth factor Cardiometabolic disorders Gh fructose drink
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