Design and characterization of a novel crosslinked, polymer and its evaluation as a control release polymer in ciprofloxacin tablets.
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Date
2024
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Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Lagos.
Abstract
Background: The new trend in the field of pharmaceutical technology is the automation of drug
delivery systems. Therefore, future generation of drug delivery systems could be derived from
engineering polymers through cross-linking.
Objective: This research work was designed to formulate an extended-release ciprofloxacin tablet
via a tailored two-component composite polymer.
Materials and methods: Hydroxypropylmethylcellulose and Gelatin (HPMC –GLT) ratios 4:0;
3:1; 2:2; 1:3 and 0:4 were cross-linked using citric acid. The batches were characterised by FTIR,
swelling index, viscosity and pH. Five batches of ciprofloxacin 250 mg mixed with hybridized
HPMC-GLT polymers ‘F1, F2, F3, F4, and F5, were prepared by wet granulation technique. The
granules were evaluated for bulk density, angle of repose and compressibility index. All crosslinked
batches were crystalline in texture. The flow rate increased with the gelatin content. The granules
were compressed on a rotary tableting machine. Tablets were evaluated for compactness and invitro
dissolution in a buffer solution for 12 hours.
Results: The T90 % for the series of batches were: 150, 132, 252, 196, and 156 minutes respectively.
Evaluation of branded ciprofloxacin tablets showed a disintegration time of 6 to 7 minutes and an
average T90 % at 30 min. The compact F3 (50 % GLT and 50 % HPMC) possessed the most desirable
tablet properties. Average crushing strength, disintegration time, friability, and the T90% were: 125
+ 5.0 N, >>30 min., 0.00 %, and 252 minutes, respectively.
Conclusion: Formulation F3 is, therefore, recommended for future optimization in the design of
controlled-release ciprofloxacin tablets.