Cofactor interactions in the activation of tissue non-specific alkaline phosphatase: Synergistic effects of Zn2+ and Mg2+ ions

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dc.contributor.authorOlorunniji, F.J.
dc.contributor.authorIgunnu, Adedoyin
dc.contributor.authorAdebayo, J.O.
dc.contributor.authorArise, R.O.
dc.contributor.authorMalomo, S.O.
dc.date.accessioned2020-05-29T15:14:49Z
dc.date.available2020-05-29T15:14:49Z
dc.date.issued2007
dc.description.abstractThe interactions of Mg2+ and Zn2+ ions in the activation of non-specific tissue alkaline phosphatase were investigated using crude extracts of rat kidney. Activation of alkaline phosphatase by the metal ions was accompanied by changes in the kinetic parameters of p nitrophenylphosphate hydrolysis. The results suggest some synergistic interactions between Mg2+ and Zn2+ ions in promoting the hydrolysis of p-nitrophenylphosphate by alkaline phosphatase. The results show that assays of alkaline phosphatase activity in homogenised tissue samples will give better responses if both Mg2+ and Zn2+ ions are included in the reactions.en_US
dc.description.sponsorshipFunded by the authors.en_US
dc.identifier.urihttps://www.ajol.info/index.php/biokem/article/view/56422
dc.identifier.urihttp://hdl.handle.net/123456789/4107
dc.language.isoenen_US
dc.publisherNigerian Society for Experimental Biologyen_US
dc.relation.ispartofseriesBiokemistri;19(2):43-48
dc.subjectAlkaline phosphataseen_US
dc.subjectkineticsen_US
dc.subjectEnzyme-cofactor interactionen_US
dc.subjectsynergismen_US
dc.titleCofactor interactions in the activation of tissue non-specific alkaline phosphatase: Synergistic effects of Zn2+ and Mg2+ ionsen_US
dc.typeArticleen_US

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