COMPARATIVE ANALYSIS OF HANDGRIP STRENGTH AND URINE C-PEPTIDE CREATININE RATIO AS BIOMARKERS FOR GLUCOSE REGULATION IN YOUNG ADULT FEMALES IN THE UNIVERSITY OF ILORIN: A CROSS-SECTIONAL STUDY
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Date
2023
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Society for Experimental Biology of Nigeria
Abstract
Handgrip strength (HGS) is a robust biomarker predicting future disability, metabolic syndrome, and
diabetes. Urinary C-peptide creatinine ratio (UCPCR) emerges as a novel, non-invasive tool under
exploration for assessing beta cell function and glucose regulation. Despite their significance in gauging
muscle strength, mass, and overall metabolic function, gaps remain in understanding the full extent of
handgrip strength and UCPCR's efficiency. This study aimed to identify a better biomarker for glucose
regulation by studying the relationship between handgrip strength, urine c-peptide creatinine ratio, and
blood glucose levels in adult females. Using ELISA, the study measured handgrip strength, blood glucose
levels, and urine samples. Social demographic data was obtained through standard questionnaires, and
statistical analysis was done using IBM 25 SPSS software with Pearson's correlation, linear regression
at P=< 0.05, and T-test. The study found that handgrip strength (HGS) had a slight non-significant
positive correlation with fasting blood sugar (FBS) (P=0.386). However, there was a significant
correlation between HGS and 2 hours postprandial glucose (2HPG) in both dominant and non-dominant
hands (P= 0.045 vs P= 0.017). Additionally, the study found that handgrip strength in the dominant hand
was significantly stronger than that in the non-dominant hand (P= 0.001). On the other hand, the urinary
C-peptide creatinine ratio (UCPCR) had no significant correlations with FBS and 2HPG. Handgrip
strength measurements provide an indicative approach for glucose regulation and are a better biomarker
for blood glucose regulation than UCPCR.
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Handgrip strength; UCPCR; fasting blood sugar; 2 hours postprandial; glucose regulation