Haematological and biomedical effects of etonogestrel subdermal implant (Implanon) in Ilorin, Nigeria

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dc.contributor.authorBalogun, Olayinka
dc.contributor.authorAdeniran, Abiodun
dc.contributor.authorAdewole, Adebayo
dc.date.accessioned2019-10-22T09:24:27Z
dc.date.available2019-10-22T09:24:27Z
dc.date.issued2016-10
dc.description.abstractObjectives: To evaluate the effect of etonogestrel subdermal implant (Implanon) on haematological and biochemical parameters of its users. Methodology: A prospective observational study among healthy women using Implanon for contraception. The study site was the family planning clinic of the University of Ilorin Teaching Hospital, Ilorin, Nigeria. Informed consent was obtained and participants were followed up for three years. Follow up parameters were haematological and biochemical evaluation at insertion (baseline), first and third years post-insertion. Statistical analysis was with SPSS-version 20.0; p value <0.05 was significant. Results: 124 participants of age 20-44years were included in the study. During the period of study, a progressive increase in the weight as well as in the level of alanine transaminase and systolic blood pressure was recorded. As compared to the baseline values, statistically significant difference in the mean values of systolic blood pressure (p<0.01), alanine transaminase (p<0.01) and weight (p=0.001) were recorded at the first year. Packed Cell Volume (p=0.001), weight (p=0.001), alanine transaminase (p=0.001) and alkaline phosphatase (p<0.05) were significant at the third year. Between the first and third year post-insertion, there was statistically significant difference in Packed Cell Volume (p=0.001), urea (p<0.05), aspartate (p=0.001) and alanine transaminase (p=0.001) and weight (p=0.001). However, there were no clinically detectable abnormalities or pregnancy during the study period. Conclusion: Haematological and biochemical parameters change with Implanon use but they were not significant to cause clinical sequelae. Implanon remains a safe long term contraceptive.en_US
dc.description.sponsorshipNilen_US
dc.identifier.urihttp://hdl.handle.net/123456789/3024
dc.language.isoenen_US
dc.publisherCollege of Medicine, Qassim University, Kingdom of Saudi Arabiaen_US
dc.subjectContraceptionen_US
dc.subjectEtonogestrel subdermal implanten_US
dc.subjectImplanonen_US
dc.subjectHaematologyen_US
dc.subjectParametersen_US
dc.subjectBiomedicalen_US
dc.titleHaematological and biomedical effects of etonogestrel subdermal implant (Implanon) in Ilorin, Nigeriaen_US
dc.typeArticleen_US

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