Serosurvey of Herpes simplex virus type-2 infection among HIV infected individuals accessing a secondary health care facility in Kwara State, North Central Nigeria.


Herpes Simplex Virus type 2 (HSV-2) is a commonly opportunistic infection among HIV seropositive subjects and acts synergistically with HIV to accelerate disease progression. This is across sectional, Hospital-based study designed to determine the prevalence of HSV-2 IgM and IgG antibodies among HIV-1infected individuals accessing the HAART Clinic of General Hospital Offa, Kwara State Nigeria. Blood samples were collected from consenting 276 (age range 11-70; mean age of 36.8 years) HIV-1 infected individuals after collecting pertinent socio-demographic data using questionnaires. The blood was separated into plasma and packed cells. The former was tested for the presence of anti- HSV-2 IgM and IgG using ELISA test kits from Diagnostic Automation INC., USA. Data were analyzed using Chi square test with SPSS version 21 software and the level of significance was determined to be P < 0.05.Out of 276 samples tested, 116 (42.0%) and 39 (14.1%) were respectively positive for HSV-2 IgG and IgM antibodies. These respectively represent latent and active HSV-2 infections. Gender, occupation and clinical state of the subjects were the main correlates of IgM serpositivity while gender, occupation, marital status and CD4+ count correlates with IgG seropositivity. The prevalence of anti-HSV-2 IgM and IgG antibodies in this cohort of HIV-infected individuals is high. There is therefore the need for routine test for HSV-2 infection among HIV infected individuals to determine the extent of infection and proper management especially the active infections



HSV-2, HIV, Serosurvey, ELISA, Offa, Antibodies.