Solvent-free synthesis, x-ray studies and in vitro inhibitory activities of copper(II) complexes of non-steroidal anti-inflammatory drugs

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dc.contributor.authorTella, A. C.
dc.contributor.authorObaleye, J. A.
dc.contributor.authorEke, U. B.
dc.contributor.authorIsaac, A. Y.
dc.contributor.authorAmeen, Mubarak
dc.date.accessioned2021-05-27T12:32:52Z
dc.date.available2021-05-27T12:32:52Z
dc.date.issued2014-04-10
dc.description.abstractSolid-state mechanochemical synthesis of [Cu(CAF)2(H2O)(OAc)]OAc co mplex 1a and [Cu(COD)2(H2O)(OAc)]OAc complex 2a were obtained by grinding stoichioetric amounts of Cu(CH3COO)2 H2O and corresponding non steroidal anti-inflammatory drugs[(caffeine (CAF) and codeine(COD)], respectively, in a mortar with pestle. Solvent-based synthesis of 1b and 2b was also carried out by reaction of metal acetate salt and each drug by refluxing at 70 C in CH3OH for 1 h for comparison purposes. The complexes 1a and 2a were characterized by comparison of elemental analysis, FT-IR, UV–Vis and 1H NMR spectra with those of the free ligand and solvent-based products (1b and 2b). The analytical and spectroscopic data of the complexes prepared via the two different methods are almost identical. X-ray diffraction patterns of the complexes prepared by mechanochemical method were different from that of the starting material suggesting formation of new metal complexes. In vitro inhibitory activities of both mechanochemical and solvent-based complexes were found to be higher than parent ligands, indicating that the antimicrobial effect of these drugs could be enhanced when they are chelated to the metal. The mechanochemical synthesis was carried out without the use of solvent or external heating. The method is faster and gives a higher yield than corresponding solvent-based reactions. The solid state reaction presented higher efficiency in terms of materials, energy and time compared to solvent-based synthesis.en_US
dc.identifier.issn0922-6168
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5489
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectSolvent-free synthesisen_US
dc.subjectCaffeineen_US
dc.subjectCodeineen_US
dc.subject1HNMRen_US
dc.subjectXRPD patternsen_US
dc.titleSolvent-free synthesis, x-ray studies and in vitro inhibitory activities of copper(II) complexes of non-steroidal anti-inflammatory drugsen_US
dc.title.alternativeResearch on Chemical Intermediatesen_US
dc.typeArticleen_US

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