Favourable pregnancy outcome following gliclazide use throughout pregnancy in diabetic female Sprague-Dawley rats

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dc.contributor.authorOjulari Lekan Sheriff
dc.contributor.authorKadir Risikat Eniola
dc.contributor.authorAbdulazeez Fatima I.
dc.contributor.authorAyinde Olarewaju Toafeek
dc.contributor.authorJimoh-Abdulghaffaar Hidaayah Oluwamayowa
dc.contributor.authorAdegoke Olufeyisipe A.
dc.date.accessioned2025-05-12T09:57:27Z
dc.date.available2025-05-12T09:57:27Z
dc.date.issued2018
dc.description.abstractObjectives: The incidence of diabetes mellitus (DM) is associated with complications with reproduction. The effect of gliclazide on pregnancy hormones and fetal outcomes in diabetic female rats was determined in this study. Methods: There were four experimental groups (control, diabetic control, gliclazide-treated and diabetictreated) of 20 rats each. Studies were carried out on days 7, 14, 19 and at term, to ascertain implantation, gestation, fetal outcome and measurement of some plasma hormone levels. Values represent mean ± SD and were analyzed by two-tailed ANOVA followed by a Post-hoc test. Differences were considered significant at p<0.05. Results: There were increases inplasma estradiol in the gliclazide-treated non-diabetic [day 14 (55.80±1.0; p=0.01), day 19 (55.80±3.1;p=0.02)] and diabetic [day 14 (25.42±1.7); p=0.03] groups, and also in plasma progesterone in the treated diabetic group [day 14 (35.12±6.2) p=0.02] only. Plasma corticosterone and plasma CRP decreased in the gliclazide-treated [corticosterone day 14 (356.30±24.1) p=0.01; day 19 (308.30±17.6) p=0.01]; [CRP day 14 (0.13±0.05) p=0.01] and the diabetic-treated [corticosterone day 14 (400.50±21.5) p=0.01, day 19 (424.10±22.4) p=0.01; [CRP day 14 (0.14±0.13) p=0.01] groups. There were no significant changes in the plasma levels of β-hCG and no abnormalities were observed in litters from all groups. Conclusion: Gliclazide improved some reproductive complications in the diabetic state and in the nondiabetic state. Consideration should be given to its use in managing reproductive complications associated with DM.
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16687
dc.language.isoen
dc.publisherLagos State University College of Medicine
dc.relation.ispartofseries2 (2); 2 -5
dc.subjectpregnancy
dc.subjectfetal outcome
dc.subjectalloxan
dc.subjectdiabetes mellitus
dc.titleFavourable pregnancy outcome following gliclazide use throughout pregnancy in diabetic female Sprague-Dawley rats
dc.typeArticle

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