Normotensive offsprings of hypertensive Nigerians have increased Left ventricular mass and abnormal geometric patterns
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Date
2012
Authors
Kolo, P.M.
Sanya, E.O.
Ogunmodede, James Ayodele
Omotoso, A.B. & Soladoye, A.O
Journal Title
Journal ISSN
Volume Title
Publisher
African Field Epidemiology Network (AFENET), Kampala, Uganda
Abstract
Background: Reports have shown that normotensive offspring of hypertensive parents (OHP) are at increased risk of developing systemic
hypertension (SH) and adverse cardiovascular events later in life. The pathological antecedents of this are thought to be alterations in the structure
and function of left ventricle. Therefore, the present study aimed at determining left ventricular mass and geometry in OHP and compared with
offspring without parental hypertension. Methods: Sixty-five OHP aged 15-25 years with 65-age and sex-matched offspring of normotensive
parents (ONP) were studied for early makers of hypertensive cardiovascular disease. Those with heart murmurs, structural heart diseases and
blood pressure ≥ 140/90 mmHg were excluded. Electrocardiography (ECG) and echocardiogram were done in standard positions. Results: Mean
left ventricular posterior wall thickness, left ventricular mass, left ventricular mass index (LVMI) and relative wall thickness (RWT) were significantly
higher in the subjects than controls (p=0.001, 0.046, 0.03 and 0.004 respectively). LVMI correlated positively with systolic and diastolic blood
pressure, waist circumference (WC), ECG voltage, and posterior wall diastolic dimension. Waist circumference was an independent predictor of
LVMI in OHP. Conclusion: We concluded that normotensive OHP have alterations in left ventricular mass and structure; and should be considered
as a special group that needs early dietary and lifestyle adjustments to prevent future cardiovascular events.
Description
Keywords
: Left ventricular mass, left ventricular geometry, echocardiogram, hypertension, hypertrophy
Citation
Pan African Medical Journal 11;6:1-5.