A COMPARATIVE STUDY OF PLASMA VITAMIN C LEVELS IN PRE-ECLAMPTIC AND NORMOTENSIVE PREGNANCIES AT THE LAGOS UNIVERSITY TEACHING HOSPITAL

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dc.contributor.authorODEIGAH, C C
dc.contributor.authorODEIGAH, L
dc.contributor.authorOLAGUNJU, FA
dc.contributor.authorSULEIMAN, ZA
dc.contributor.authorISSA, FY
dc.contributor.authorADESINA, KT
dc.contributor.authorSAIDU, R
dc.contributor.authorRAJI, HA
dc.contributor.authorAYENI, MO
dc.contributor.authorJIMOH, AAG
dc.date.accessioned2021-12-16T11:23:21Z
dc.date.available2021-12-16T11:23:21Z
dc.date.issued2015
dc.description.abstractBackground: Pre-eclampsia remains a major cause of maternal and perinatal morbidity and mortality in our environment. Research into methods of prevention of this disorder has been hampered by a poor understanding of the pathological mechanisms leading to pre-eclampsia. Recent studies suggest that oxidative stress (with reduced antioxidant defences) could lead to free radical mediated endothelial dysfunction in pre-eclampsia. Objectives: To determine the plasma vitamin C levels in pre-eclamptic and normotensive pregnant patients at LUTH, and to compare the levels of plasma vitamin C in both groups of patients with a view to investigate the association between plasma vitamin C level and pre-eclampsia. Method: A comparative study of plasma vitamin C levels in pre-eclamptic and normotensive pregnancies. Informed consent was obtained from 90 women admitted to the labour ward with singleton pregnancies between 28 and 40 weeks, who were divided into two groups: 30 pre-eclamptic patients and 60 normotensive patients (each pre-eclamptic patient was matched for parity with 2 normotensive patients). Venous blood was obtained from all the participants. Plasma vitamin C level was measured using High Performance Liquid Chromatography (HPLC). Data was analyzed using inferential statistical methods. Results: The results showed that mean plasma vitamin C level in the pre-eclamptic women was 119.3 ± 23.7 μg/ml, while the mean plasma vitamin C level in the normotensive pregnant patients was 246.5 ± 45.0 μg/ml. The mean concentration of plasma vitamin C level was significantly lower in the pre-eclamptic patients than in the normotensive patients (t=14.5; p<0.001) Conclusion: The study showed that pre-eclampsia is associated with decreased concentration of plasma vitamin C. There is the need for a local study to investigate the effect of vitamin C supplementation on pre-eclampsia.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/7185
dc.language.isoenen_US
dc.publisherDEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, LAGOS UNIVERSITY TEACHING HOSPITAL (LUTH).LAGOS **DEPARTMENT OF FAMILY MEDICINE UNIVERSITY OF ILORIN TEACHING HOSPITAL ***DEPARTMENT OF ANAESTHESIA ^DEPARTMENT OF COMMUNITY MEDICINE AND EPIDEMIOLOGY ^^DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY UNIVERSITY OF ILORIN/UNIVERSITY OF ILORIN TEACHING HOSPITALen_US
dc.subjectPre-eclampsiaen_US
dc.subjectpre-eclamptic pregnanciesen_US
dc.subjectnormotensive pregnanciesen_US
dc.subjectplasma vitamin C levelen_US
dc.titleA COMPARATIVE STUDY OF PLASMA VITAMIN C LEVELS IN PRE-ECLAMPTIC AND NORMOTENSIVE PREGNANCIES AT THE LAGOS UNIVERSITY TEACHING HOSPITALen_US
dc.typeArticleen_US

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